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Correlation between carotid intima-media thickness and the activity of rheumatoid arthritis : a 1-year cross-sectional study
Joint Authors
Source
Journal of the Bahrain Medical Society
Issue
Vol. 30, Issue 3 (30 Sep. 2018), pp.34-41, 8 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Bahrain
No. of Pages
8
Main Subjects
Abstract EN
Background and objectives: Among several non invasive techniques available, a high-resolution B-mode ultrasonography is the widely used technique to measure carotid intima-media thickness (CIMT) in rheumatoid arthritis (RA) patients with elevated cardiovascular risk.
The present study was undertaken to explore the clinical relationship between CIMT and disease activity in patients with RA.
Methods: This study involved 50 adult patients with RA.
Demographic, physical, systemic, and clinical data and history of the patients were recorded.
Investigations, such as erythrocyte sedimentation rate, highly sensitive C-reactive protein, renal and liver function tests, RA factor, and anticyclic citrullinated peptide antibody tests were performed.
CIMT was assessed using high resolution B-mode ultrasonography and the disease severity was assessed based on disease activity score (DAS) 28.
Results: The mean age of the RA patients was 49.88 ± 12.12 years with male predilection.
The mean duration, mean European League Against Rheumatism (EULAR) criteria score, and mean DAS 28 score in RA patients were 3.62 ± 3.25 years, 8.10 ± 1.58, and 4.91 ± 1.11, respectively.
The mean CIMT observed in RA patients was 0.94 ± 0.31 cm.
Significant difference was observed in the mean CIMT values of different variables, including duration of joint pain (P = 0.007), tender joint count(P < 0.001), swollen joint count (P < 0.001), EULAR criteria score (P < 0.001), and DAS 28 score(P < 0.001).
Also, CIMT correlated positively with tender joint count (r = 0.711; P < 0.001), swollen joint count (r = 0.673; P < 0.001), EULAR criteria score (r = 0.611; P < 0.001), and DAS 28 score (r = 0.729; P < 0.001).
Conclusion: A strong correlation was observed between CIMT and disease activity in patients with RA.
Hence, CIMT can be a useful surrogate marker for detecting atherosclerosis in patients with RA.
American Psychological Association (APA)
Maldar, Arif& Suhas M.. 2018. Correlation between carotid intima-media thickness and the activity of rheumatoid arthritis : a 1-year cross-sectional study. Journal of the Bahrain Medical Society،Vol. 30, no. 3, pp.34-41.
https://search.emarefa.net/detail/BIM-886687
Modern Language Association (MLA)
Maldar, Arif& Suhas M.. Correlation between carotid intima-media thickness and the activity of rheumatoid arthritis : a 1-year cross-sectional study. Journal of the Bahrain Medical Society Vol. 30, no. 3 (Sep. 2018), pp.34-41.
https://search.emarefa.net/detail/BIM-886687
American Medical Association (AMA)
Maldar, Arif& Suhas M.. Correlation between carotid intima-media thickness and the activity of rheumatoid arthritis : a 1-year cross-sectional study. Journal of the Bahrain Medical Society. 2018. Vol. 30, no. 3, pp.34-41.
https://search.emarefa.net/detail/BIM-886687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 40-41
Record ID
BIM-886687