Study of contrast-induced oxidative stress in nondiabetic patients undergoing coronary angiography
Joint Authors
Jeyaseelan, L.
Vinapamula, Kiranmayi S.
Bitla, Aparna R.
Manda, Prasanth
Srinivasa Rao, P. V. L. N.
Rajasekhar, D.
Vishnubhotla, Sivakumar
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 1 (28 Feb. 2019), pp.45-52, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-02-28
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Administration of iodinated contrast media is associated with serious compli- cations such as acute kidney injury (AKI).
Oxidative stress is implicated as a major mechanism underlying the production of contrast-induced AKI (CI-AKI).
There are very few human studies on oxidative stress occurring after contrast administration.
Twenty-seven patients scheduled for coronary angiography were recruited.
An average of 22.2 mL low-osmolal nonionic contrast was administered.
Plasma conjugated dienes (CD), lipid hydroperoxides (LOOH), malondialdehyde (MDA), protein carbonyl (PC), protein thiols (PTs), ferric reducing ability of plasma (FRAP), erythrocyte super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase were estimated before, 30 min, 2 and 4 h after contrast administration.
CD, LOOH, MDA, and PC increased (P <0.001), whereas PTs, FRAP, SOD, CAT (P <0.001), and GPx (P = 0.013) decreased in the first 4 h.
Estimated glomerular filtration rate (eGFR) showed inverse association with MDA and positive association with GPx.
The study provides evidence for oxidative stress following contrast administration even in the absence of predisposing factors.
Association of eGFR with MDA and GPx indicate kidney as the source of oxidative stress.
Hence, antioxidant therapy before contrast administration helps to prevent the development of oxidative stress, thereby reducing the risk of CI-AKI.
American Psychological Association (APA)
Manda, Prasanth& Srinivasa Rao, P. V. L. N.& Bitla, Aparna R.& Vinapamula, Kiranmayi S.& Jeyaseelan, L.& Rajasekhar, D.…[et al.]. 2019. Study of contrast-induced oxidative stress in nondiabetic patients undergoing coronary angiography. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 1, pp.45-52.
https://search.emarefa.net/detail/BIM-887113
Modern Language Association (MLA)
Manda, Prasanth…[et al.]. Study of contrast-induced oxidative stress in nondiabetic patients undergoing coronary angiography. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 1 (Jan. / Feb. 2019), pp.45-52.
https://search.emarefa.net/detail/BIM-887113
American Medical Association (AMA)
Manda, Prasanth& Srinivasa Rao, P. V. L. N.& Bitla, Aparna R.& Vinapamula, Kiranmayi S.& Jeyaseelan, L.& Rajasekhar, D.…[et al.]. Study of contrast-induced oxidative stress in nondiabetic patients undergoing coronary angiography. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 1, pp.45-52.
https://search.emarefa.net/detail/BIM-887113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 51-52
Record ID
BIM-887113