Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis
Joint Authors
Idris, Fahd
Paley, Michael A.
Gaut, Joseph P.
Ranganathan, Prabha
Vijayan, Anitha
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 1 (28 Feb. 2019), pp.226-230, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-02-28
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Hydralazine is a commonly used anti-hypertensive medication.
It can, however, contribute to the development of autoimmunity, in the form of drug-induced lupus and anti- neutrophil cytoplasmic antibodies-associated vasculitis.
We report a 45-year-old patient with hypertension managed with hydralazine for four years who presented with rapidly progressive glomerulonephritis (RPGN), requiring hemodialysis, and diffuse alveolar hemorrhage (DAH), requiring mechanical ventilation, and extracorporeal membrane oxygenation.
The patient’s autoantibody profile was consistent with a drug-induced autoimmune process and renal histology revealed focal necrotizing crescentic GN.
She was treated with high-dose steroids, plasma exchange and rituximab.
DAH resolved and her renal function improved, allowing discontinuation of hemodialysis.
This case reveals that rituximab can be successfully used in the setting of hydralazine-induced vasculitis, including critically ill patients with severe DAH and acute kidney injury from RPGN.
American Psychological Association (APA)
Paley, Michael A.& Idris, Fahd& Gaut, Joseph P.& Ranganathan, Prabha& Vijayan, Anitha. 2019. Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 1, pp.226-230.
https://search.emarefa.net/detail/BIM-887133
Modern Language Association (MLA)
Idris, Fahd…[et al.]. Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 1 (Jan. / Feb. 2019), pp.226-230.
https://search.emarefa.net/detail/BIM-887133
American Medical Association (AMA)
Paley, Michael A.& Idris, Fahd& Gaut, Joseph P.& Ranganathan, Prabha& Vijayan, Anitha. Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 1, pp.226-230.
https://search.emarefa.net/detail/BIM-887133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 229-230
Record ID
BIM-887133