Cytogenotoxic effects of adenium obesum seeds extracts on breast cancer cells
Joint Authors
al-Anzi, Khalid M.
Abu Tarbush, Faysal M.
Abu al-Farah, Muhammad
Hailan, Walid A. Q.
Ali, Ahmad Qasim
Ajmal Ali, Muhammad
Mahmud, Ahmad Husam
Lee, Joongku
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 3 (31 Mar. 2019), pp.547-553, 7 p.
Publisher
Publication Date
2019-03-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
The extracts prepared from various areal parts of the Adenium obesum (Forssk.) Roem.
& Schult.
(Family: Apocynaceae) including leaves, fruit and seeds ethanolic extracts and seed aqueous extract were evaluated against MCF-7 cells in order to investigate its potential of cytogenotoxicity and induction of apoptosis.
The ethanolic seeds extract had comparatively higher cytotoxicity (IC50 337 mg/ml).
Further, apoptosis and DNA damaging potential of seeds ethanolic extract was analyzed by applying multiple sub-lethal concentrations and durations.
Flow cytometry results revealed that maximum percentage of early apoptosis (37%) and late apoptosis (35%) were observed after 12 h exposure in concentrations 200 mg/ml and 300 mg/ml, respectively.
Similarly, the higher effect of extract in terms of DNA damage by alkaline comet assay was registered after 12 h treatment at concentrations 200 and 300 mg/mL.
The calculated total damage score (TDS) for these concentrations were 614 and 617, respectively.
The above findings indicate that A.
obesum ethanolic seeds extracts has cytogenotoxic properties that could be further explored for the potential source of chemotherapeutic lead against cancer
American Psychological Association (APA)
Ali, Ahmad Qasim& Abu al-Farah, Muhammad& Abu Tarbush, Faysal M.& al-Anzi, Khalid M.& Ajmal Ali, Muhammad& Lee, Joongku…[et al.]. 2019. Cytogenotoxic effects of adenium obesum seeds extracts on breast cancer cells. Saudi Journal of Biological Sciences،Vol. 26, no. 3, pp.547-553.
https://search.emarefa.net/detail/BIM-887236
Modern Language Association (MLA)
Ali, Ahmad Qasim…[et al.]. Cytogenotoxic effects of adenium obesum seeds extracts on breast cancer cells. Saudi Journal of Biological Sciences Vol. 26, no. 3 (Mar. 2019), pp.547-553.
https://search.emarefa.net/detail/BIM-887236
American Medical Association (AMA)
Ali, Ahmad Qasim& Abu al-Farah, Muhammad& Abu Tarbush, Faysal M.& al-Anzi, Khalid M.& Ajmal Ali, Muhammad& Lee, Joongku…[et al.]. Cytogenotoxic effects of adenium obesum seeds extracts on breast cancer cells. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 3, pp.547-553.
https://search.emarefa.net/detail/BIM-887236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 552-553
Record ID
BIM-887236