Inferring transcription factors and micrornas associated with elevated expression of the oncogenic B-Cell Lymphoma 11A in triple negative breast cancer
Other Title(s)
التعرف على الجينات المسؤولة عن زيادة تعبير جين B-Cell Lymphoma 11A في سرطان الثدي ثلاثي السلبية
Joint Authors
Laqtum, Nuf Nasir
al-Qathmi, Khulud Mubarak
Bakhuraybah, Amani Hasan
Source
Journal of King Abdulaziz University : Medical Sciences
Issue
Vol. 23, Issue 3 (30 Sep. 2016), pp.9-21, 13 p.
Publisher
King Abdulaziz University Scientific Publishing Center
Publication Date
2016-09-30
Country of Publication
Saudi Arabia
No. of Pages
13
Main Subjects
Abstract EN
B-cell lymphoma 11A, a transcriptional repressor, is highly expressed in triple negative breast cancer.
The in vitro studies and animal models provide initial evidence suggesting that the knockdown of B-cell lymphoma 11A has a therapeutic eff ect on breast cancer.
Defi ning the regulators driving the high expression of B-cell lymphoma 11A is important to understand its cancer-related functions.
Among these regulators, transcription factors and microRNAs are critical for gene expression and associated with expression perturbations.
Firstly, we identifi ed the transcription factors that potentially interact with B-cell lymphoma 11A promoter.
Based on bioinformatics prediction and multiple Omics datasets, two upregulated transcriptional activators Zinc Finger BED-Type Containing 4 and E2F Transcription Factor 1 in triple negative breast cancer were found to have seven sites within B-cell lymphoma 11A promoter.
Secondly, we aimed to determine a putative set of microRNA that can mediate the post-transcriptional repression of B-cell lymphoma 11A.
miR-513a-5p, miR-139-5p, miR1179, miR-140-5p, and miR-542-3p, harboring at least one site of interaction with B-cell lymphoma 11A 3' untranslated region, were found inhibited in triple negative breast cancer.
Taken together, the combinatorial regulation by transcription factors and microRNAs provide valuable information for further investigation on controlling the expression level of B-cell lymphoma 11A in triple negative breast cancer.
American Psychological Association (APA)
Laqtum, Nuf Nasir& al-Qathmi, Khulud Mubarak& Bakhuraybah, Amani Hasan. 2016. Inferring transcription factors and micrornas associated with elevated expression of the oncogenic B-Cell Lymphoma 11A in triple negative breast cancer. Journal of King Abdulaziz University : Medical Sciences،Vol. 23, no. 3, pp.9-21.
https://search.emarefa.net/detail/BIM-887601
Modern Language Association (MLA)
Laqtum, Nuf Nasir…[et al.]. Inferring transcription factors and micrornas associated with elevated expression of the oncogenic B-Cell Lymphoma 11A in triple negative breast cancer. Journal of King Abdulaziz University : Medical Sciences Vol. 23, no. 3 (2016), pp.9-21.
https://search.emarefa.net/detail/BIM-887601
American Medical Association (AMA)
Laqtum, Nuf Nasir& al-Qathmi, Khulud Mubarak& Bakhuraybah, Amani Hasan. Inferring transcription factors and micrornas associated with elevated expression of the oncogenic B-Cell Lymphoma 11A in triple negative breast cancer. Journal of King Abdulaziz University : Medical Sciences. 2016. Vol. 23, no. 3, pp.9-21.
https://search.emarefa.net/detail/BIM-887601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 18-20
Record ID
BIM-887601