An overview of the apoptosis mechanism in endothelial cells
Other Title(s)
نظرة عامة عن آلية موت خلايا البطانة الدموية
Joint Authors
al-Abd al-Munim, Walid Ibrahim
al-Uhaydib, Faysal Muhammad
al-Sadah, Husayn Mahfuz
Source
Journal of the North for Basic and Applied Sciences
Issue
Vol. 4, Issue 1 (31 May. 2019), pp.77-91, 15 p.
Publisher
Northern Border University Scientific Publishing Center
Publication Date
2019-05-31
Country of Publication
Saudi Arabia
No. of Pages
15
Main Subjects
Topics
Abstract EN
Tissue factor (TF) has a non-coagulant role in cell proliferation, migration and metastasis.
An overexpression of TF leads to a variety of diseases, such as thrombosis in cancer, metastasis and angiogenesis.
In contrast, TF can induce apoptosis in endothelial cells via the mechanism of inhibiting formation of the TF–β1 integrin complex.
The cell undergoes apoptosis due to loss of cell attachment (Anoikis), resulting in reduced Src activity in the cell.
The β1 integrin affects Src activity during TF signalling.
The mechanism involves the activation of a protein 38 (P38) mitogen-activated protein kinase (MAPK) and caspases coupled with P53 activation.
Prolonged overexpression of TF inside the cell induces cell signaling for apoptosis.
This pathway involves activating Src to stimulate cell proliferation.
The result reveals a significant effect of β1 integrin inhibition on the level of Src phosphorylation indicating the relationship between the β1 integrin and Src during cell apoptosis.
Amutation in the TF 253 sequence is capable of inducing apoptosis in endothelial cells.
The β1-integrin inhibition and the mutant-TF Ala 253 are both major factors in inducing apoptosis.
American Psychological Association (APA)
al-Abd al-Munim, Walid Ibrahim& al-Uhaydib, Faysal Muhammad& al-Sadah, Husayn Mahfuz. 2019. An overview of the apoptosis mechanism in endothelial cells. Journal of the North for Basic and Applied Sciences،Vol. 4, no. 1, pp.77-91.
https://search.emarefa.net/detail/BIM-888539
Modern Language Association (MLA)
al-Abd al-Munim, Walid Ibrahim…[et al.]. An overview of the apoptosis mechanism in endothelial cells. Journal of the North for Basic and Applied Sciences Vol. 4, no. 1 (May. 2019), pp.77-91.
https://search.emarefa.net/detail/BIM-888539
American Medical Association (AMA)
al-Abd al-Munim, Walid Ibrahim& al-Uhaydib, Faysal Muhammad& al-Sadah, Husayn Mahfuz. An overview of the apoptosis mechanism in endothelial cells. Journal of the North for Basic and Applied Sciences. 2019. Vol. 4, no. 1, pp.77-91.
https://search.emarefa.net/detail/BIM-888539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 86-91
Record ID
BIM-888539