Serum interleukin-18 as a novel biomarker for disease activity of systemic lupus erythematosus patients
Joint Authors
Sharif, Muhammad H.
Jawdah, Fatimah al-Zahra E.
al-Shal, Amal S.
Abd al-Sattar, Amal Bakri Ahmad
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 49, Issue 1 (30 Apr. 2019), pp.145-152, 8 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2019-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Interleukin-18 (IL-18) is a vital cytokine, which mediated organ failure and elevated in autoimmune disorders as Systemic Lupus Erythematosus.
This study investigated the importance role of IL-18 as a diagnostic marker for disease activity of systemic lupus erythematosus (SLE) and development of lupus nephritis (LN).
This cross-sectional study was carried out on 41 SLE patients with LN, 31 lupus non-nephritis patients and 20 healthy controls.
The IL-18 serum levels were measured by IL-18 ELISA kit, to evaluate the activity of Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score.
The results showed significant increase in serum IL-18 level in patients with LN (174.09±33.19) than both lupus non nephritis patients (9139.45±64.39) and healthy control (46.06±16.42), with significant correlation between IL-18 level and SLEDAI
American Psychological Association (APA)
al-Shal, Amal S.& Sharif, Muhammad H.& Abd al-Sattar, Amal Bakri Ahmad& Jawdah, Fatimah al-Zahra E.. 2019. Serum interleukin-18 as a novel biomarker for disease activity of systemic lupus erythematosus patients. Journal of the Egyptian Society of Parasitology،Vol. 49, no. 1, pp.145-152.
https://search.emarefa.net/detail/BIM-888995
Modern Language Association (MLA)
al-Shal, Amal S.…[et al.]. Serum interleukin-18 as a novel biomarker for disease activity of systemic lupus erythematosus patients. Journal of the Egyptian Society of Parasitology Vol. 49, no. 1 (Apr. 2019), pp.145-152.
https://search.emarefa.net/detail/BIM-888995
American Medical Association (AMA)
al-Shal, Amal S.& Sharif, Muhammad H.& Abd al-Sattar, Amal Bakri Ahmad& Jawdah, Fatimah al-Zahra E.. Serum interleukin-18 as a novel biomarker for disease activity of systemic lupus erythematosus patients. Journal of the Egyptian Society of Parasitology. 2019. Vol. 49, no. 1, pp.145-152.
https://search.emarefa.net/detail/BIM-888995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 150-152
Record ID
BIM-888995