Characterization of HLA-DRB1 alleles polymorphisms in plasmodium falciparum Malaria infections in Jazan, KSA
Joint Authors
Zaki, Wafa M.
Zaydan, Hanan Z.
Madkhali, Ayman M.
Madkhali, Khawlah M..
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 49, Issue 1 (30 Apr. 2019), pp.173-182, 10 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2019-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Malaria is a public health problem in the KSA.
It is restricted to the southwestern region, where P.
falciparum is the most prevalent species.
The immune response which affects the clinical outcome of malaria is genetically controlled and is influenced with high degree of HLA genetic polymorphism.
The present study aimed at assessing the relationship between HLA-DRB1 alleles and malaria susceptibility pattern moreover its degree of severity in a group of Saudi population in Jazan, KSA.
A total of 60 malaria cases (51 uncomplicated and 9 severe malaria cases) and 60 control subjects were enrolled in this study.
Blood samples were collected and genotyping of the HLA-DRB1 alleles was performed.
The results suggested significant associations of HLA-DRB1* 04 and HLA-DRB1* 11 with susceptibility to malaria (p = 0.002 and p = 0.043, respectively) and association of HLA-DRB1* 13 with resistance to malaria (p = 0.032).
The HLA-DRB1* 04 was found to be associated with severe malaria.
The individuals with HLA-DRB1* 04 and HLA-DRB1* 11 were at increased risk to malaria infection and the HLA-DRB1* 04 carriers are more susceptible to severe malaria.
While, HLA-DRB1* 13 carriers are more resistant to this infection.
Wide investigations for this association may lead to implementation of a successful effective malaria vaccine program
American Psychological Association (APA)
Zaki, Wafa M.& Zaydan, Hanan Z.& Madkhali, Ayman M.& Madkhali, Khawlah M... 2019. Characterization of HLA-DRB1 alleles polymorphisms in plasmodium falciparum Malaria infections in Jazan, KSA. Journal of the Egyptian Society of Parasitology،Vol. 49, no. 1, pp.173-182.
https://search.emarefa.net/detail/BIM-888998
Modern Language Association (MLA)
Zaki, Wafa M.…[et al.]. Characterization of HLA-DRB1 alleles polymorphisms in plasmodium falciparum Malaria infections in Jazan, KSA. Journal of the Egyptian Society of Parasitology Vol. 49, no. 1 (Apr. 2019), pp.173-182.
https://search.emarefa.net/detail/BIM-888998
American Medical Association (AMA)
Zaki, Wafa M.& Zaydan, Hanan Z.& Madkhali, Ayman M.& Madkhali, Khawlah M... Characterization of HLA-DRB1 alleles polymorphisms in plasmodium falciparum Malaria infections in Jazan, KSA. Journal of the Egyptian Society of Parasitology. 2019. Vol. 49, no. 1, pp.173-182.
https://search.emarefa.net/detail/BIM-888998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 180-182
Record ID
BIM-888998