Hydroxyurea : pattern of use, patient adherence, and safety profile in patients with sickle cell disease in Oman
Joint Authors
George, Prasad
al-Sadiq, Rifat Abd Allah
Jimmy, Beena
Jose, Jimmy
Source
Issue
Vol. 34, Issue 4 (31 Jul. 2019), pp.327-335, 9 p.
Publisher
Publication Date
2019-07-31
Country of Publication
Oman
No. of Pages
9
Main Subjects
Topics
Abstract EN
Objectives: Many barriers contribute to the underutilization of hydroxyurea (HU) in the treatment of sickle cell disease (SCD), and adherence to its use is often reported to be suboptimal.
It is important to have information on the safety of HU in patients with SCD.
Our study assessed the pattern of use, patients’ adherence to medication, discontinuation of use, and safety of HU in patients with SCD.
Methods: This cross-sectional study was conducted in the department of medicine of a referral hospital in Oman over five months and included a review of patient files and patient interview.
Approval was obtained from the Regional Research and Ethics Committee of the A'Dakhiliyah Governorate and the hospital administration.
The parameters were compared between groups using the chi-square test.
Results: Of 298 patients studied, 128 (43.0%) had used HU at some points.
The difference in the prevalence of HU use was statistically significant based only on age (p = 0.014), with younger patients more likely to be currently using HU or used HU in the past.
The majority of patients were adherent (82.5%) based on self-reported adherence.
The prevalence of discontinuation (temporary or permanent) of HU use was high (57.0%), and suspected adverse drug reaction (ADR) was the most common reason.
Among those who had never used HU, 33.7% of patients had an indication for the initiation of HU.
A quarter of patients who used HU developed a suspected ADR, with blood abnormalities being the commonest.
The duration of HU use influenced ADR prevalence (p = 0.015).
Conclusions: Among the current users of HU, the majority of the patients were adherent based on self-reported medication adherence.
The prevalence of discontinuation of HU use and instances of non-initiation of HU among those indicated were high.
A larger study, ideally of a prospective nature, in various governorates of Oman, would provide a wider picture at the national level.
American Psychological Association (APA)
Jose, Jimmy& al-Sadiq, Rifat Abd Allah& Jimmy, Beena& George, Prasad. 2019. Hydroxyurea : pattern of use, patient adherence, and safety profile in patients with sickle cell disease in Oman. Oman Medical Journal،Vol. 34, no. 4, pp.327-335.
https://search.emarefa.net/detail/BIM-890657
Modern Language Association (MLA)
Jose, Jimmy…[et al.]. Hydroxyurea : pattern of use, patient adherence, and safety profile in patients with sickle cell disease in Oman. Oman Medical Journal Vol. 34, no. 4 (Jul. 2019), pp.327-335.
https://search.emarefa.net/detail/BIM-890657
American Medical Association (AMA)
Jose, Jimmy& al-Sadiq, Rifat Abd Allah& Jimmy, Beena& George, Prasad. Hydroxyurea : pattern of use, patient adherence, and safety profile in patients with sickle cell disease in Oman. Oman Medical Journal. 2019. Vol. 34, no. 4, pp.327-335.
https://search.emarefa.net/detail/BIM-890657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 333-335
Record ID
BIM-890657