Micro spectrophotometric determination and cloud point extraction of sulphadimidine sodium in pure form and pharmaceutical drug
Other Title(s)
التقدير الطيفي المايكروي و الاستخلاص بنقطة الغيمة للسلفاديمادين الصوديوم في المركبات النقية و المستحضرات الصيدلانية
Joint Authors
Abd al-Ghani, Ruqayah Hashim
Zahir, Sadiyah Ahmad
Kazim, Isra Amir
Source
Issue
Vol. 16, Issue 2 (30 Jun. 2019), pp.332-344, 13 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Topics
Abstract EN
Two simple, rapid, and useful spectrophotometric methods were suggest or the determination of sulphadimidine sodium (SDMS) with and without using cloud point extraction technique in pure form and pharmaceutical preparation.
The first method was based on diazotization of the Sulphdimidine Sodium drug by sodium nitrite at 5 ºC, followed by coupling with α –Naphthol in basic medium to form an orange colored product .
The product was stabilized and its absorption was measured at 473 nm.
Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1.
Sandell’s sensitivity was 0.03012 μg∙cm-1, the detection limit was 0.0277 μg∙ml-1, and the limit of Quantitation was 0.03605μg∙ml-1.The second method was the cloud point extraction (CPE) using Trtion X-114 as surfactant.
Beer’s law was obeyed in the concentration range of (1-12) μg∙ml-1.
Sandell’s sensitivity was 0.02958 μg∙cm-1, the detection limit was 0.01745 μg∙ml-1, and the limit of quantitation was 0.028303 μg∙ml-1.
All variables including the reagent concentration, reaction time, color stability period, and mole ratio were studied in order to optimize the reaction conditions.
The mole ratio for the composition of product is (1 : 1).
Both methods were effectively useful to the determination of sulphdimidine sodium in pharmaceutical dose form.
The attained results were in a good agreement with the official and other methods in the literature .No interference were observed from the commonly encountered additives and excipients.
American Psychological Association (APA)
Zahir, Sadiyah Ahmad& Kazim, Isra Amir& Abd al-Ghani, Ruqayah Hashim. 2019. Micro spectrophotometric determination and cloud point extraction of sulphadimidine sodium in pure form and pharmaceutical drug. Baghdad Science Journal،Vol. 16, no. 2, pp.332-344.
https://search.emarefa.net/detail/BIM-890876
Modern Language Association (MLA)
Kazim, Isra Amir…[et al.]. Micro spectrophotometric determination and cloud point extraction of sulphadimidine sodium in pure form and pharmaceutical drug. Baghdad Science Journal Vol. 16, no. 2 (2019), pp.332-344.
https://search.emarefa.net/detail/BIM-890876
American Medical Association (AMA)
Zahir, Sadiyah Ahmad& Kazim, Isra Amir& Abd al-Ghani, Ruqayah Hashim. Micro spectrophotometric determination and cloud point extraction of sulphadimidine sodium in pure form and pharmaceutical drug. Baghdad Science Journal. 2019. Vol. 16, no. 2, pp.332-344.
https://search.emarefa.net/detail/BIM-890876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 343-344
Record ID
BIM-890876