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Association between ENAM polymorphisms and dental caries in children
Joint Authors
Divakar, Darshan Devang
Mustafa, Muhammad
al-Anzi, Sultan Ali S.
Asiri, Muhammad Yahya A.
Halawani, Shahd Muhammad
al-Shahri, Salih Zayd
al-Umari, Said Ahmad Said
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 4 (31 May. 2019), pp.730-735, 6 p.
Publisher
Publication Date
2019-05-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Aim : Dental enamel, the most rigid biological tissue of the tooth known to mankind, is the most integral and fundamental part of the tooth.
Enamel matrixes compile 5 % of Enamelin peptides and at the time of tooth development, they are considered to effect the formation and elongation of enamel crystallites.
ENAM plays critical role in enamel formation.
Any changes in ENAM may affect the thickness of enamel and may lead to dental caries.
The present study is aimed to evaluate the association of ENAM gene polymorphisms and susceptibility of dental caries development risk.
Material and methods: The present study was carried out on 168 South Indian children, children’s with dental caries were included in study.
Written consent was taken from their parents/guardians.
Additionally 193 healthy individuals were enrolled as controls.
Sampling was done after dental examination of the individuals.
Three ENAM gene single nucleotide polymorphisms (SNPs) were rs7671281, rs3796704 and rs12640848 was genotyped to check their role in susceptibility of dental caries development risk.
Results: Out of three SNPs rs7671281 showed statistically significant risk association with dental caries susceptibility in this ethnic population at heterozygous allele CT (OR : 1.939, p = .01865) and with minor allele T (OR : 1.451, p = .001292).
SNP rs3796704 showed significant protective association with dental caries in Indian population at heterozygous allele GA (OR : 0.409, p = .0192) and with minor allele A (OR: 0.645, p = .00875).
SNP rs12640848 showed significant protective association with dental caries in Indian population at heterozygous allele AG (OR: 3.041, p = .00642) and with minor allele G (OR: 1.478, p = .02184).
Preliminary insilico analysis also showed that rs7671281 (Ile648Thr) amino acid change will cause the structural and functional changes in ENAM protein.
Conclusions: In the present study significant association was observed between ENAM gene SNP rs7671281 and dental caries susceptibility in South Indian children.
These results suggested that ENAM gene variants may contribute to dental caries in children.
American Psychological Association (APA)
Divakar, Darshan Devang& al-Anzi, Sultan Ali S.& Asiri, Muhammad Yahya A.& Halawani, Shahd Muhammad& al-Shahri, Salih Zayd& al-Umari, Said Ahmad Said…[et al.]. 2019. Association between ENAM polymorphisms and dental caries in children. Saudi Journal of Biological Sciences،Vol. 26, no. 4, pp.730-735.
https://search.emarefa.net/detail/BIM-891133
Modern Language Association (MLA)
Divakar, Darshan Devang…[et al.]. Association between ENAM polymorphisms and dental caries in children. Saudi Journal of Biological Sciences Vol. 26, no. 4 (May. 2019), pp.730-735.
https://search.emarefa.net/detail/BIM-891133
American Medical Association (AMA)
Divakar, Darshan Devang& al-Anzi, Sultan Ali S.& Asiri, Muhammad Yahya A.& Halawani, Shahd Muhammad& al-Shahri, Salih Zayd& al-Umari, Said Ahmad Said…[et al.]. Association between ENAM polymorphisms and dental caries in children. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 4, pp.730-735.
https://search.emarefa.net/detail/BIM-891133
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 734-735
Record ID
BIM-891133