Effect of Shuangjinlian mixture on oral ulcer model in rat

Abstract EN

Objective : To observe the effect of common clinical drug Shuangjin Lian mixture on rats with oral ulcer and discuss its mechanism.

Methods: Sodium carboxymethyl cellulose caused leukocyte aggregation in rats, observed the antiinflammatory effect of Shuangjin mixture.

3 mm * 3 mm size ulcer surface in the oral cavity of rats was caused by 90 % phenol solution, to observe the therapeutic effect and anti-inflammatory effect of Shuangjinlian mixture on rats with oral ulcers.

Result: The low, middle and high dose Shuangjinlian mixture can inhibits the accumulation of white blood cells caused by sodium carboxymethyl cellulose in rats significantly (P < 0.01).

And reduce the degree of edema and hyperaemia around the ulcer tissue significantly (P < 0.01), improve the ulcer healing probability, and reduce the level of TNF-a, VEGF levels and increase IL-2 level in the serum of rats with oral ulcers significantly (P < 0.01).

Pathological examination showed that the lesion of ulcer tissue in each treatment group was obviously alleviated.

Conclusion : Shuangjinlian mixture had anti-inflammatory effect and was effective for the prevention and treatment of oral ulcer in rats.