Role of Sepia sp. extract against toxicity induced by benzene in male rats

Abstract EN

Benzene is a highly toxic chemical agent, therefore, the present study was carried out to investigate the protective effects of cephalopoda extract (Sepia sp.) against benzene toxicity in male white albino rats.

Twenty four white male rats were used, these animals were divided into four groups, each group contain six animals as a following: the first group (control group) treated orally with normal saline (1 ml/ kg-1) for two weeks, the second group (benzene group) injected I.P.

with benzene 0.5 ml/kg at first day of each week for two week the third group treated intraperitoneally (I.P.) with Sepia sp.

extract (720 μg/ rat) for two week, , and the fourth group (benzene + extract) injected I.P.

with benzene 0.5 ml/kg at first day of each week for two week, then injected I.P.

with extract 720 μg/animals for two weeks.

The result indicated nonsignificant increase in the level of the AST, and a significant increase in levels of ALT, cholesterol, triglyceride, LDL, VLDL of male rats treated with benzene compared with control group.

Also, there was a significant decreased in HDL in the second group compared with the control group.

Protective activity of Sepia sp.

extract against toxicity of benzene observed in decreasing of ALT, AST, cholesterol and triglyceride, LDL and VLDL levels, and increased in the HDL level.