Study the effects of extracted Octacosanol and Atorvastatin on leukocytes in female Norwegian rats

Abstract EN

The present study was designed to compare some of hematological parameters in female norwegian rats (Ratus norvigicus) after administration of extracted octacosanol and atorvastatin.

Thirty-two females rat with (10-12) weeks old-and weighting (200-250 gm) were used in the current study.

Policosanol was extracted from sugarcane that obtained from Mesan province.

Octacosanol is determined in this extraction by gas chromatography – mass spectrometry (GC/MS).

Animals were divided into 4 equal groups: Group.1 (n=8) (Control): only 0.٥ ml/ kg of Dimethyl Sulphoxide (DMSO).

Group.2 (n=8) animals treated with (0.02 mg/ kg) of standard octacosanol.

Group.3 (n=8) animals treated with (0.02mg/ kg) of octacocosanol extraction, Group.

4 (n=8) treated with only (0.02mg/ kg) of atorvastatine.

The treatment continued for 30 days.

All animals were then sacrificed and blood samples were collected in EDTA tubes for measuring of total and different count of WBC.