The relationship between the genotypes frequency for the PRM1 gene and some of risk factors in male infertile of Thi Qar Province

Abstract EN

This study was designed to study the Protamine /1 gene role and it is contribution to the risk of male Infertile in Infertility Center at AL-Hussein Teaching Hospital Thi Qar Province.

Highly Percentage of primary infertility (76.5%) compared with secondary infertility (23.5%).Current study noticed significant different between male infertility and homozygous mutant (AA) when OR=1.684 and Heterozygous mutant (CA) when OR=5.150 .The prevalence of the frequency of Homogenous mutant for PRM1 gene is higher among urban (46%) than in rural areas compared with the prevalence of the frequency of heterozygous mutant for PRM1 gene (20%) is among urban than in rural areas.

patients who have Homozygous mutant for PRM1 gene with a family history had a higher risk (40%) compared to those without a family history it noticed significant different more than one and half times (OR=1.625) .

The results showed that the significant difference between patients and healthy controls when genotype AA (OR= 1.684) is more than one and a half times , otherwise the genotype CA showed a high significant difference between the two groups patients and control five times (OR= 5.150), Current study showed no correlation between genotypes in people smoking and the risk of male infertility in genotype AA where there were not significant differences (OR= 0.882) , While genotype CA showed a significant difference by more than one and a half times (OR=1.803).

Current study showed a correlation between genotype of PRM1 gene for the patients ages more than 40 years and the risk of male infertility increased more than two times (OR=1.625).