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Synthesis, characterization, and cytotoxicity study of some pyridine chalcone derivatives
Other Title(s)
تحضير و تشخيص و دراسة السمية لبعض مشتقات الجالكون البريذينية
Joint Authors
al-Shawi, Ali Abd al-Wahid Abd al-Husayn
Shihab, Nizar Latif
Nimah, Husayn Falih
Source
Journal of Basrah Researches : Sciences
Issue
Vol. 45, Issue 1A (31 Mar. 2019), pp.14-31, 18 p.
Publisher
University of Basrah College of Education for Pure Sciences
Publication Date
2019-03-31
Country of Publication
Iraq
No. of Pages
18
Main Subjects
Abstract EN
Currently, chalcone derivatives are an interest research for the designing a new compounds as anticancer agents due to the privilate structure of chalcone compounds in the drug discovery system.
In this study, we synthesized 5 chalcone derivates which are (CH (A) , CH (B) , CH (C) , CH (E) , and CH (D)) from the reaction of substituted acetophenone with 2- pyridine carboxyaldehyde by using Claisen- Schmidt condensation method and catalyze the reaction by KOH pellets.
After purification process, the yield was good to characterize them by using chemical structure analysis (FTIR, C13NMR, Mass spectrum), which approved their structures.
Cytotoxicity evaluation was with 100 μM for each concentration compound against Human Breast Cancer MDA-MB231 Cells and we identified two pyridine chalcone derivatives showed a moderate action.
The results of toxicity evaluation pave a forward step to develop new anticancer agents as from pyridine chalcones as a lead structure.
American Psychological Association (APA)
Nimah, Husayn Falih& Shihab, Nizar Latif& al-Shawi, Ali Abd al-Wahid Abd al-Husayn. 2019. Synthesis, characterization, and cytotoxicity study of some pyridine chalcone derivatives. Journal of Basrah Researches : Sciences،Vol. 45, no. 1A, pp.14-31.
https://search.emarefa.net/detail/BIM-891868
Modern Language Association (MLA)
Nimah, Husayn Falih…[et al.]. Synthesis, characterization, and cytotoxicity study of some pyridine chalcone derivatives. Journal of Basrah Researches : Sciences Vol. 45, no. 1A (2019), pp.14-31.
https://search.emarefa.net/detail/BIM-891868
American Medical Association (AMA)
Nimah, Husayn Falih& Shihab, Nizar Latif& al-Shawi, Ali Abd al-Wahid Abd al-Husayn. Synthesis, characterization, and cytotoxicity study of some pyridine chalcone derivatives. Journal of Basrah Researches : Sciences. 2019. Vol. 45, no. 1A, pp.14-31.
https://search.emarefa.net/detail/BIM-891868
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 21-30
Record ID
BIM-891868