Risk for opioid abuse is diminished by inhibiting aldehyde dehydrogenase-2 (ALDH-2)‎ in rats

Joint Authors

Levin, Edward D.
Wells, Corinne
Diamond, Ivan
Rezvani, Amir H.
Strumph, Peter
Blackburn, Brent K.

Source

Journal of Drug and Alcohol Research

Issue

Vol. 8, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.

Publisher

Ashdin Publishing Corporation

Publication Date

2019-12-31

Country of Publication

Egypt

No. of Pages

6

Main Topic

Public Health

Abstract EN

Significant opiate addiction is known to follow prescribed opiate use for pain.

There is a serious unmet need for non-addicting medications to prevent subsequent opiate addiction after a short period of opioid treatment for temporary pain.

Recent evidence indicates that selective inhibition of aldehyde dehydrogenase-2 (ALDH-2) reduces drugseeking and trained self-administration of alcohol, cocaine and nicotine, apparently by preventing a concomitant surge of dopamine in the ventral tegmental area (VTA) and nucleus accumbens (NAc).

Activation of the same dopaminergic pathway is also implicated in opioid-induced reinforcement.

Therefore, we asked whether the selective ALDH-2 inhibitor, ANS-6637, would attenuate opioid selfadministration in drug-naïve rats for opioid self-administration.

Rats received oral doses of ANS-6637 (9, 18, 36 or 72 mg/kg) or an equal volume of control vehicle 2 h before exposure to remifentanil and a light cue to accentuate self-administration over 5 consecutive days.

Self-administration and the numbers of lever presses on both active and inactive levers were recorded.

ANS-6637 significantly reduces remifentanil self-administration over 5 sessions of treatment in rats without prior exposure to remifentanil.

We also confirm that the highest dose of ANS-6637 (72 mg/kg) used in this study did not prevent remifentanil-induced analgesia using a classic hot plate test.

Thus, ANS-6637 significantly reduces of initial exposure to remifentanil selfadministration without affecting desired analgesia.

These preliminary observations suggest that ANS-6637 appears to have potential value as a non-addictive therapeutic agent to prevent abuse of commonly used opiates in initiating pain management.

American Psychological Association (APA)

Rezvani, Amir H.& Wells, Corinne& Strumph, Peter& Diamond, Ivan& Blackburn, Brent K.& Levin, Edward D.. 2019. Risk for opioid abuse is diminished by inhibiting aldehyde dehydrogenase-2 (ALDH-2) in rats. Journal of Drug and Alcohol Research،Vol. 8, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-891953

Modern Language Association (MLA)

Rezvani, Amir H.…[et al.]. Risk for opioid abuse is diminished by inhibiting aldehyde dehydrogenase-2 (ALDH-2) in rats. Journal of Drug and Alcohol Research Vol. 8 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-891953

American Medical Association (AMA)

Rezvani, Amir H.& Wells, Corinne& Strumph, Peter& Diamond, Ivan& Blackburn, Brent K.& Levin, Edward D.. Risk for opioid abuse is diminished by inhibiting aldehyde dehydrogenase-2 (ALDH-2) in rats. Journal of Drug and Alcohol Research. 2019. Vol. 8, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-891953

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 5-6

Record ID

BIM-891953