A biochemical study of agarwood on methanol injection in rat
Author
Source
Journal of Drug and Alcohol Research
Issue
Vol. 8, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Topics
Abstract EN
Agarwood has antioxidant, anti-inflammatory, neuroleptic and sedative effects along with other benefits.
Reactive oxygen species (ROS) are produced during the detoxification of alcohols, xenobiotics and drugs, which generates oxidative stress, inflammation, apoptosis and injuries.
The effect of Agarwood extracts on nitric oxide (NO), malondialdehyde (MDA), acetylcholinesterase (AChE), COX-2 (cyclooxygenase-2), LOX (lipoxygenase), caspase-3, TNF-α (tumor necrosis factor-α), monoamine oxidase (MAO) and DNAF (DNA fragmentation) levels in the liver and brain separately in rats treated and untreated with methanol was studied.
The injection of rats with methanol caused an elevation in liver and brain NO, MDA, ACHE, COX-2, LOX, TNF-α, Caspase-3, MAO and DNAF compared to the control.
Treatment of animals with Agarwood extract pre, during and post-methanol administration improved the liver’s and brain’s biological parameters versus the methanol group.
We therefore indicated that Agarwood diminished oxidative stress and apoptosis induced by methanol, and this may be based on a protective effect of Agarwood chemical compositions.
American Psychological Association (APA)
Hamudah, Asma F.. 2019. A biochemical study of agarwood on methanol injection in rat. Journal of Drug and Alcohol Research،Vol. 8, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-891955
Modern Language Association (MLA)
Hamudah, Asma F.. A biochemical study of agarwood on methanol injection in rat. Journal of Drug and Alcohol Research Vol. 8 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-891955
American Medical Association (AMA)
Hamudah, Asma F.. A biochemical study of agarwood on methanol injection in rat. Journal of Drug and Alcohol Research. 2019. Vol. 8, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-891955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 12-14
Record ID
BIM-891955