Study effects of oral contraceptive on some hormones hematological parameters and testis of experimental male rat

Abstract EN

Oral contraceptive, Birth control, pills are mainly used to prevent the pregnancy.

The combination of progesterone and estrogen are commonly use in these days.

In this paper, we aimed to determine the influence of progesterone and estrogen as synthetic chemical found in oral contraceptive pills on male rats.

we investigated the contribution of oral contraceptive on 2 groups of male rats.

25 and 50mg/kg a had been given through gavage for 60 days.

Level of testosteronealso were measured utilizing Minvids.

Determination of red blood cells, RBCs, total white blood cells and platelets PLwhere been counted using coulter counter.

There was a significant influence of oral contraceptive pills on WBC and PLT while there are not significant effect of RBC comparing to the control.

Moreover, in the current study level of Testosterone was not significantly affected due to treatments comparing to the control in both groups.

Eosin and Hematoxylin stain used to make histological sections of testiest and the results showed that normal spermatogenesis can be seen clearly in the control group after 60 days’ exposure.

The spermatogenesis is disrupted based on dose where 50mg of oral contraceptive exposure showed very high level of disturbance.

Reductions in the normal designand abnormal distance in seminiferous tubules also noticed after 60 day’s treatment with oral contraceptive.

In addition to reduce the number of germ cells and somatic cells population after 50mg exposure are counted in high level of contraceptive taken.