New-onset diabetes mellitus after the first attack of acute pancreatitis : a systematic review and meta-analysis
Joint Authors
Hu, Cunliang
Liu, Qiuping
Chen, Niwei
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 21, Issue 7 (31 Jul. 2019), pp.1-12, 12 p.
Publisher
Publication Date
2019-07-31
Country of Publication
United Arab Emirates
No. of Pages
12
Main Subjects
Topics
Abstract EN
Context: New-onset diabetes mellitus (DM) after the first attack of acute pancreatitis (AP) has not been fully elucidated.
Objectives: The study aimed to explore the incidence and time-course of pancreatic endocrine insufficiency in patients with newonset prediabetes or DM after the first attack of AP.
Data Sources: A comprehensive literature review was conducted by searching four major biomedical journal databases (PubMed, Embase, Cochrane Library, andWeb of Science).
Study Selection: We included all prospective clinical studies that investigated the change in the metabolization of glucose after hospital discharge following the first attack of AP.
Data Extraction: After quality assessment, data were extracted according to a standard protocol.
Because of between-study heterogeneity, data were analyzed by the random-effects method.
Results: The inclusion criteria were met by 12 clinical studies, including 766 patients with the first attack of AP.
Prediabetes and/or DM was observed in 51% (95% CI: 55% to 63%) of the patients after the first attack of AP.
The pooled incidence of prediabetes and DM after AP was 23% (95% CI: 16% to 30%) and 18% (95% CI: 11% to 26%), respectively.
The risk of new-onset prediabetes andDMsignificantly increased in 1 - 3 years (relative risk (RR): 4.00 (95% CI: 1.68 - 9.53)) and 3 - 5 years (RR: 2.12 (95% CI: 1.9 - 3.8)), respectively.
Conclusions: New-onset prediabetes and/orDMafter the first attack of AP developed in 51% of the patients after hospital discharge and the risk of DM increased more than two folds over three years.
American Psychological Association (APA)
Hu, Cunliang& Liu, Qiuping& Chen, Niwei. 2019. New-onset diabetes mellitus after the first attack of acute pancreatitis : a systematic review and meta-analysis. Iranian Red Crescent Medical Journal،Vol. 21, no. 7, pp.1-12.
https://search.emarefa.net/detail/BIM-892342
Modern Language Association (MLA)
Hu, Cunliang…[et al.]. New-onset diabetes mellitus after the first attack of acute pancreatitis : a systematic review and meta-analysis. Iranian Red Crescent Medical Journal Vol. 21, no. 7 (Jul. 2019), pp.1-12.
https://search.emarefa.net/detail/BIM-892342
American Medical Association (AMA)
Hu, Cunliang& Liu, Qiuping& Chen, Niwei. New-onset diabetes mellitus after the first attack of acute pancreatitis : a systematic review and meta-analysis. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 7, pp.1-12.
https://search.emarefa.net/detail/BIM-892342
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 12
Record ID
BIM-892342