استقصاء طفرات الإكسون 11 لجين c-kit لدى عدد من مرضى الورم السدوي المعدي المعوي السوريين المستجيبين و غير المستجيبين ل Imatinib
Other Title(s)
Investigation of exon 11 mutations in c-kit gene in a number of Imatinib responders and non-responders Syrian gastrointestinal stromal tumor patients
Joint Authors
Source
Issue
Vol. 8, Issue 7 (30 Apr. 2019)8 p.
Publisher
Syrian Clinical Laboratory Association
Publication Date
2019-04-30
Country of Publication
Syria
No. of Pages
8
Main Subjects
Abstract EN
Gastrointestinal stromal tumor (GIST) is a sarcoma arising from mesenchymal layer in the muscular wall of the gastrointestinal tract.
C-kit gene mutations are involved in the emergence and development of this tumor.
Exon 11 mutations of c-kit gene represent two-thirds of these mutations.
Imatinib is the first-line treatment for GIST.
Although more than half of the patients show a response to the treatment, a proportion of them do not respond.
Whereas Patients who show exon 11 mutations are the most responsive to the treatment.
Recent approaches for GIST treatment with imatinib request c-kit mutations analysis mainly present on exon 11.
Our study aimed to verify the presence or absence of exon 11 mutations in a number of imatinib responsive and non-responsive patients.
This retrospective study included seven GIST patients (n=7), four of them were responsive to treatment (4/7) and three patients were not (3/7).
Sequencing of exon 11 c-kit gene in DNA extracted from specimens preserved for these patients was performed.
Our results proved the presence of exon 11 mutations in responsive patients, and their absence in non-responders.
Our findings suggest the necessity of adopting this investigation in setting the protocol of treatment of these patients.
American Psychological Association (APA)
فرعون، نور ومنعم، فوزة. 2019. استقصاء طفرات الإكسون 11 لجين c-kit لدى عدد من مرضى الورم السدوي المعدي المعوي السوريين المستجيبين و غير المستجيبين ل Imatinib. مجلة التشخيص المخبري،مج. 8، ع. 7.
https://search.emarefa.net/detail/BIM-892574
Modern Language Association (MLA)
فرعون، نور ومنعم، فوزة. استقصاء طفرات الإكسون 11 لجين c-kit لدى عدد من مرضى الورم السدوي المعدي المعوي السوريين المستجيبين و غير المستجيبين ل Imatinib. مجلة التشخيص المخبري مج. 8، ع. 7 (نيسان 2019).
https://search.emarefa.net/detail/BIM-892574
American Medical Association (AMA)
فرعون، نور ومنعم، فوزة. استقصاء طفرات الإكسون 11 لجين c-kit لدى عدد من مرضى الورم السدوي المعدي المعوي السوريين المستجيبين و غير المستجيبين ل Imatinib. مجلة التشخيص المخبري. 2019. مج. 8، ع. 7.
https://search.emarefa.net/detail/BIM-892574
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية
Record ID
BIM-892574