Therapeutic role of curcumin loaded magnetic nanoparticles against gamma-irradiation hazards in rats
Joint Authors
Salih, H. M. A.
Abd al-Maqsud, H. A.
Hasanayn, W. F.
Subayh, E. I.
Husayn, Sayyid A.
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 52, Issue 3 (31 Jul. 2019), pp.64-73, 10 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The present study has been carried out to investigate the possible therapeutic effect of curcumin loaded iron oxide nanoparticles (MNP-CUR) administered through intraperitoneal (i.p) injection after whole body gamma irradiation of rats.
Whole body gamma irradiation of rats at 6 Gy (single dose) caused significant reduction in red blood cells count, hemoglobin levels, lymphocytes, neutrophils, and monocytes associated with highly significant elevation in malondialdehyde (MDA).
The reduction in catalase (CAT) activity and the reduced levels of glutathione GSH were observed after three weeks post-irradiation.
Administration of MNP-CUR after irradiation resulted in a significant improvement of the hematological parameters andreduced changes in MDA, GSH and CAT levels were induced by gamma irradiation.The combination of MNP and CUR was found to be advantageous for the after-exposure treatment because the effect of radiation is stealth.
An individual may spend days, weeks or even months exposed to radiation doses without becoming alarmed.
Exposure to ionizing radiation is known to have an effect on the body cells, especially the blood cells and cause a marked decline in their viability and proliferation.
American Psychological Association (APA)
Abd al-Maqsud, H. A.& Husayn, Sayyid A.& Salih, H. M. A.& Hasanayn, W. F.& Subayh, E. I.. 2019. Therapeutic role of curcumin loaded magnetic nanoparticles against gamma-irradiation hazards in rats. Arab Journal of Nuclear Sciences and Applications،Vol. 52, no. 3, pp.64-73.
https://search.emarefa.net/detail/BIM-892615
Modern Language Association (MLA)
Abd al-Maqsud, H. A.…[et al.]. Therapeutic role of curcumin loaded magnetic nanoparticles against gamma-irradiation hazards in rats. Arab Journal of Nuclear Sciences and Applications Vol. 52, no. 3 (Jul. 2019), pp.64-73.
https://search.emarefa.net/detail/BIM-892615
American Medical Association (AMA)
Abd al-Maqsud, H. A.& Husayn, Sayyid A.& Salih, H. M. A.& Hasanayn, W. F.& Subayh, E. I.. Therapeutic role of curcumin loaded magnetic nanoparticles against gamma-irradiation hazards in rats. Arab Journal of Nuclear Sciences and Applications. 2019. Vol. 52, no. 3, pp.64-73.
https://search.emarefa.net/detail/BIM-892615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 71-73
Record ID
BIM-892615