Carboxymethyl cellulose as a green and biodegradable catalyst for the solvent-free synthesis of benzimidazoloquinazolinone derivatives

Abstract EN

Carboxymethyl cellulose (CMC) was used as an efficient, and environmentally friendly catalyst for the solvent-free three-component synthesis of quinazolinone derivatives by condensation of 2-aminobenzimidazole, dimedone or 1,3-cyclohexanedione, and different aldehydes.

The catalyst was recovered easily, and reused without significant loss of its activity.

Solvent-free and mild reaction conditions, nontoxic-, biodegradable-, and inexpensive catalyst, environmentally benign method, and high to excellent yields are some important features of this protocol.