Experimental study of drug delivery system for prednisolone loaded and released by Mesoporous Silica MCM-41

Other Title(s)

دراسة تجريبية لنظام توصيل دواء البريدنيزولون المحمل و المحرر من قبل السليكا MCM-41

Joint Authors

Jassam, Abd al-Qadir Abd al-Amir
al-Bayati, Talib Muhammad Nayif

Source

al-Khwarizmi Engineering Journal

Issue

Vol. 15, Issue 1 (31 Mar. 2019), pp.117-124, 8 p.

Publisher

University of Baghdad al-Khwarizmi College of Engineering

Publication Date

2019-03-31

Country of Publication

Iraq

No. of Pages

8

Main Subjects

Chemistry

Topics

Abstract EN

In the present study, nanoporous material type MCM-41 was prepared by the sol-gel technique and was used as a carrier for prednisolone (PRD) drug delivery.

The structural properties of mesoporous were fully characterized by X-ray diffraction (XRD), N2 adsorption /desorption and Fourier-transform infrared (FTIR).

The mass transfer in term of adsorption process (loading) and desorption process (releasing) properties were investigated.

The maximum drug loading efficiency was equal to 38% and 47.5% at different concentrations.

The PRD released was prudently studied in water media of pH 6.8 simulated body fluid (SBF) in according to "United State Pharmacopeia (USP38)".

The results proved that the release of prednisolone from MCM-41 was (69.4%) after 24 hr.

The data of the released PRD was found to be submitted to a Korsmeyer–Peppas model.

American Psychological Association (APA)

al-Bayati, Talib Muhammad Nayif& Jassam, Abd al-Qadir Abd al-Amir. 2019. Experimental study of drug delivery system for prednisolone loaded and released by Mesoporous Silica MCM-41. al-Khwarizmi Engineering Journal،Vol. 15, no. 1, pp.117-124.
https://search.emarefa.net/detail/BIM-893127

Modern Language Association (MLA)

al-Bayati, Talib Muhammad Nayif& Jassam, Abd al-Qadir Abd al-Amir. Experimental study of drug delivery system for prednisolone loaded and released by Mesoporous Silica MCM-41. al-Khwarizmi Engineering Journal Vol. 15, no. 1 (Mar. 2019), pp.117-124.
https://search.emarefa.net/detail/BIM-893127

American Medical Association (AMA)

al-Bayati, Talib Muhammad Nayif& Jassam, Abd al-Qadir Abd al-Amir. Experimental study of drug delivery system for prednisolone loaded and released by Mesoporous Silica MCM-41. al-Khwarizmi Engineering Journal. 2019. Vol. 15, no. 1, pp.117-124.
https://search.emarefa.net/detail/BIM-893127

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 122-123

Record ID

BIM-893127