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Therapeutic efficacy of chitosan nanoparticles loaded with albendazole on parenteral phase of experimental trichinellosis
Joint Authors
Nasif, Nashat E.
Muharram, Ismail M.
Atiyyah, Amani F.
Barakat, Riham M.
Abu Husayn, Nuha M.
Shams al-Din, Asma
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 49, Issue 2 (31 Aug. 2019), pp.301-311, 11 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2019-08-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Most of the drugs used for trichinellosis treatment showed a limited bioavailability, a high degree of resistance and a weak activity against encapsulated larvae.
Therefore, there is an urgent need to develop new agents to improve the bioavailability of these drugs.
So, the aim of the present study was to assess the use of chitosan (CH) nanoparticles alone or loaded with full and half dose albendazole (ABZ) to increase albendazole dissolution rate, to enhance its antiparasitic activity during the muscular phases of T.
spiralis infection.
Fifty male albino mice were used.
They were divided into six experimental groups.
Two control groups each includes five mice and four infected treated groups each includes ten mice.
Chitosan nanoparticles were used orally at a dose of 100mg/kg/day starting from the 31st -day post infection (dpi) for seven successive days either alone or loaded with full dose or half dose of ABZ.
Results revealed a significant improvement in all treated groups with the highest reduction rate (97.3%) of muscle larval counts, improvement of muscular histopathological changes, and degeneration of encysted larvae with minimal pathologic changes of infected skeletal muscles.
A significant decrease in inducible nitric oxide synthetize (iNOS) expression in muscle tissues was in mice treated by CH loaded with a full dose of ABZ compared to control group
American Psychological Association (APA)
Nasif, Nashat E.& Muharram, Ismail M.& Atiyyah, Amani F.& Barakat, Riham M.& Abu Husayn, Nuha M.& Shams al-Din, Asma. 2019. Therapeutic efficacy of chitosan nanoparticles loaded with albendazole on parenteral phase of experimental trichinellosis. Journal of the Egyptian Society of Parasitology،Vol. 49, no. 2, pp.301-311.
https://search.emarefa.net/detail/BIM-893255
Modern Language Association (MLA)
Nasif, Nashat E.…[et al.]. Therapeutic efficacy of chitosan nanoparticles loaded with albendazole on parenteral phase of experimental trichinellosis. Journal of the Egyptian Society of Parasitology Vol. 49, no. 2 (Aug. 2019), pp.301-311.
https://search.emarefa.net/detail/BIM-893255
American Medical Association (AMA)
Nasif, Nashat E.& Muharram, Ismail M.& Atiyyah, Amani F.& Barakat, Riham M.& Abu Husayn, Nuha M.& Shams al-Din, Asma. Therapeutic efficacy of chitosan nanoparticles loaded with albendazole on parenteral phase of experimental trichinellosis. Journal of the Egyptian Society of Parasitology. 2019. Vol. 49, no. 2, pp.301-311.
https://search.emarefa.net/detail/BIM-893255
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 309-311
Record ID
BIM-893255