Bone mineral density and vitamin d status in children with remission phase of steroid-sensitive nephrotic syndrome
Joint Authors
Cetin, Nuran
Gencler, Aylin
Sivrikoz, Ilknur Ak
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 4 (31 Aug. 2019), pp.853-862, 10 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-08-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
Children with idiopathic nephrotic syndrome are primarily treated with glucocorticoids (GCs), but long-term GC use can lead to undesired side effects.
We investigated the bone mineral density (BMD) and 25-hydroxyvitamin D (25-OH D) levels in children with the remission phase of steroid-sensitive nephrotic syndrome (SSNS).
This study included 32 patients with SSNS who had not received GC treatment in the last 6 months and a control group of 20 healthy children.
Serum levels of calcium, phosphate, alkaline phosphatase, 25-(OH)D, and parathyroid hormone (PTH) were measured.
BMD was determined in the lumbar spinal region using dual-energy X-ray absorptiometry (DEXA).
Serum 25-(OH)D levels were lower in the SSNS patients than in the healthy children (P <0.05), with 22 patients (68.8%) having Z-scores <−1.
The Z-scores were positively correlated with 25-(OH)D levels (r = 0.424, P <0.05).
PTH levels were higher in patients with osteoporosis than in patients with Z-scores ≥−1 (P <0.05).
Bone mineral content and BMD were positively correlated with the age of diagnosis (P <0.01).
Receiver-operating characteristic curve analysis showed that the cutoff value of 25-(OH)D levels for predicting low BMD was 14.67 ng/mL with a sensitivity of 90% and a specificity of 64%.
The area under the curve (AUC ± standard error) was 0.868 ± 0.064 (95% confidence interval: 0.742– 0.994, P = 0.001).
Decreased 25-(OH)D levels and the negative effects of long-term GC treatment on BMD persist in SSNS remission phase.
Levels of 25-(OH)D <14.67 ng/mL could predict abnormal DEXA scans in children with SSNS remission phase
American Psychological Association (APA)
Cetin, Nuran& Gencler, Aylin& Sivrikoz, Ilknur Ak. 2019. Bone mineral density and vitamin d status in children with remission phase of steroid-sensitive nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 4, pp.853-862.
https://search.emarefa.net/detail/BIM-893720
Modern Language Association (MLA)
Cetin, Nuran…[et al.]. Bone mineral density and vitamin d status in children with remission phase of steroid-sensitive nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 4 (Jul. / Aug. 2019), pp.853-862.
https://search.emarefa.net/detail/BIM-893720
American Medical Association (AMA)
Cetin, Nuran& Gencler, Aylin& Sivrikoz, Ilknur Ak. Bone mineral density and vitamin d status in children with remission phase of steroid-sensitive nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 4, pp.853-862.
https://search.emarefa.net/detail/BIM-893720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 860-862
Record ID
BIM-893720