Assessment role of coenzyme q10 on some physiological and biochemical parameters in resembling type ii diabetic rats

Abstract EN

Diabetes mellitus is a syndrome characterized by chronic hyperglycemia and disturbances of carbohydrates, fats and protein metabolism associated with absolute or relative deficiencies in insulin secretion and / or resistance to the action of insulin.

The present investigation was conducted to observe however, Co Q10 improves the antioxidant defense system and changes in the metabolisms of carbohydrate and lipid in diabetic rats.

Thirty adult albino rats (Rattus rattus) were divided into three groups (ten for each).

The first group was fed a standard laboratory diet for 3 weeks (control), the second fed on standard diet in addition to 10 % fructose in drinking water (fructose rats) and the third one was treated by coenzyme Q10 (10 mg / kg i.p daily) and 10 % fructose in drinking water.

Body weight, food and water intake of all rats were recorded.

At the end of 3 weeks, rats were killed and fasting blood samples were obtained.

Serum glucose, insulin, lipid profile, leptin, lipid peroxidation, SOD, catalase and glutathione were measured.

The results showed that serum glucose, insulin, cholesterol, triglyceride, LDL-C, VLDL, atherogenic index, leptin, lipid peroxidation and SOD were significantly (p < 0.05) elevated in fructose fed rats than both control and fructose with coenzyme Q10 supplementation.

On the contrary, a significant (p < 0.05) decline were recorded in the level of serum HDL-C, HDL ratio, catalase and glutathione (GSH) of fructose rats group as compared to the control rats.

The administration of Co-enzyme Q10 to rats fed on fructose improved deranged carbohydrate and lipid metabolism occur as a result of feeding fructose.

However, this amelioration did not reach to the levels recorded in the control group.