Correlation of bilirubin and alkaline phosphatase in infantile patients with cholestasis

Abstract EN

Background : Early and successful individualized management of infantile cholestasis depends on the time of diagnosis.

Objective : The objective of the study is to assess the clinical value of serum total bilirubin, direct bilirubin, and alkaline phosphatase in children with cholestasis.

Materials and Methods : Sixty patients with diseases and 25 healthy controls distributed into three groups – total/direct bilirubin, and alkaline phosphatase were measured for all case and control studies by enzyme‑linked immunosorbent assay.

Results: The results showed serum total, direct bilirubin, and alkaline phosphatase have a highly significantly elevated in intra‑ and extra‑hepatic cholestasis groups when compared with control (P < 0.001).

There was a significantly elevated serum total and direct bilirubin when compared the extrahepatic cholestatic group with intrahepatic cholestatic group (P = 0.002 and 0.017), and there was no statistical difference between the intrahepatic cholestatic patients and extrahepatic cholestatic group when serum alkaline phosphatase measured (P = 0.610).

Conclusion: From these findings, it was concluded that the level of direct bilirubin in sera of extrahepatic cholestasis group when compared with intrahepatic cholestasis group is elevated, serum total bilirubin, and alkaline phosphatase levels are good markers in determining the poor prognosis of cholestasis disease.