Everolimus worsening chronic proteinuria in patient with diabetic nephropathy post liver transplantation
Joint Authors
Arman, Farid
Hanna, Rami M.
Yanny, Beshoy
Barsoum, Marina
Mikhail, Mira
al-Baghdadi, Maha
Wallace, William
Sab, Sami
Rastogi, Anjay
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 4 (31 Aug. 2019), pp.989-994, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-08-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Mammalian target of rapamycin (mTOR) inhibitors are used in renal sparing protocols and transplant immunosuppression in patients with solid organ and stem cell transplants.
They cause various side effects, including proteinuria, which is mediated by blockade of the vascular endothelial growth factor receptor pathway.
There have been various reports of mTOR inhibitors causing proteinuria or worsening proteinuria form preexisting renal glomerulopathies.
We report a 73-year old male with diabetic glomerulosclerosis, acute liver failure due to Budd–Chiari syndrome, chronic low platelets, and worsening proteinuria from 0.46 g protein/g creatinine to 2.2 g protein/g creatinine.
Workup revealed no thrombotic microangiopathy through skin biopsy, and a renal biopsy confirmed only clinically suspected diabetic and hypertensive glomerulosclerosis and possible calcineurin inhibitors.
On discontinuation of everolimus urine protein decreased back to 0.6 g/g creatinine.
We review the mechanism of mTOR-induced proteinuria and how this may affect diabetic nephropathy secondarily.
We also consider the clinical implications of this in transplant patients receiving these agents.
American Psychological Association (APA)
Hanna, Rami M.& Yanny, Beshoy& Arman, Farid& Barsoum, Marina& Mikhail, Mira& al-Baghdadi, Maha…[et al.]. 2019. Everolimus worsening chronic proteinuria in patient with diabetic nephropathy post liver transplantation. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 4, pp.989-994.
https://search.emarefa.net/detail/BIM-893833
Modern Language Association (MLA)
Hanna, Rami M.…[et al.]. Everolimus worsening chronic proteinuria in patient with diabetic nephropathy post liver transplantation. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 4 (Jul. / Aug. 2019), pp.989-994.
https://search.emarefa.net/detail/BIM-893833
American Medical Association (AMA)
Hanna, Rami M.& Yanny, Beshoy& Arman, Farid& Barsoum, Marina& Mikhail, Mira& al-Baghdadi, Maha…[et al.]. Everolimus worsening chronic proteinuria in patient with diabetic nephropathy post liver transplantation. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 4, pp.989-994.
https://search.emarefa.net/detail/BIM-893833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 993-994
Record ID
BIM-893833