Effect of vitamin D deficiency on pulmonary function test in a normal population

Abstract EN

Background : During the past years, the role of Vitamin D on wide biologic processes has received the attractiveness.

Moreover, the role of Vitamin D in the prevention and treatment of respiratory infections has already been confirmed.

Objective: In the present study, the pulmonary functions, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) ratio, and FEV1/FVC ratio were compared between healthy individuals with and without Vitamin D deficiency.

Materials and Methods: In the current case–control study, the pulmonary functions of healthy individuals with normal Vitamin D (control = 51) and with Vitamin D deficiency (cases = 57) were compared through statistical analysis.

The individuals recruited in the study were screened from the outpatient clinic of medicine department of a public hospital purposively.

The Vitamin D level <50 nmol/L was considered deficient.

The reference values of pulmonary functions were considered as follows: FVC between 80 % and 120 % as normal and <80% as reduced; FEV1 ≥75 as normal and <75 as reduced; FEV1/FVC between 80 % and 120 % as normal.

Results : The present study showed that individuals with normal level of Vitamin D (control) and those with deficient level of Vitamin D (case) were comparable in age (39.09 vs.

41.33 years; P = 0.393), and body mass index (27.48 vs.

28.39; P = 0.475), respectively.

In addition, both case and control groups were similar in FVC (93.98 vs.

93.12; P = 0.653), FEV1 (90.88 vs.

89.39L; P = 0.752), and FEV1/ FVC (95.94 vs.

95.01 %; P = 0.777) respectively.

Conclusion: The study did not show a significant difference in baseline characteristics and of those spirometry functions (FVC, FEV1, and FEV1/FVC) between the healthy individuals with normal and deficient Vitamin D levels.