The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension : a meta-analysis
Joint Authors
Fajar, Jonny Karunia
Susanti, Melly
Pikir, Budi Susetio
Saka, Putu Nina Berlinda
Sidarta, Erdo Puncak
Tamara, Fredo
Akbar, Rizal Rahmanda
Hutama, Saga Aditya
Gunawan, Atma
Heriansyah, Teuku
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 20, Issue 1 (31 Jan. 2019), pp.1-13, 13 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2019-01-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Topics
Abstract EN
Background: Since first reported having the association with essential hypertension, angiotensin II type 1 receptor (AT1R) A1166C was globally investigated worldwide.
However, controversy was found.
Furthermore, previous meta- analyses did not adequate to clarify the precise correlation due to some limitations.
Therefore, we aimed to perform a meta-analysis concerning the association between AT1R A1166C single-nucleotide polymorphism (SNP) and the risk of essential hypertension with eliminating the limitations of previous studies.
Methods: A meta-analysis was conducted from February to March 2019.
Some information related to sample size of hypertension and control groups and genotype frequencies of hypertension and control groups were extracted from each study.
Data were analyzed using fixed or random effect model to determine the overall correlation.
Results: A total of 45 papers consisting of 11911 cases and 1340 controls were enrolled for the study.
Our overall analysis showed that C allele and AC genotype of AT1R A1166C was associated with 1.18-fold and 1.15-fold respectively increased risk of essential hypertension, while the decreased risk of essential hypertension was observed in A allele and AA genotype In sub-group analysis, increased risk of essential hypertension was found in C allele, AC genotype, and CC genotype of both Asian population and PCR-RFLP sub-groups, while decreased risk was observed in A allele and AA genotype.
Conclusions: Our meta-analysis reveals that AT1R A1166C remains a valuable SNP having an association with the risk of essential hypertension.
American Psychological Association (APA)
Fajar, Jonny Karunia& Pikir, Budi Susetio& Susanti, Melly& Saka, Putu Nina Berlinda& Sidarta, Erdo Puncak& Tamara, Fredo…[et al.]. 2019. The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension : a meta-analysis. The Egyptian Journal of Medical Human Genetics،Vol. 20, no. 1, pp.1-13.
https://search.emarefa.net/detail/BIM-893847
Modern Language Association (MLA)
Fajar, Jonny Karunia…[et al.]. The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension : a meta-analysis. The Egyptian Journal of Medical Human Genetics Vol. 20, no. 1 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-893847
American Medical Association (AMA)
Fajar, Jonny Karunia& Pikir, Budi Susetio& Susanti, Melly& Saka, Putu Nina Berlinda& Sidarta, Erdo Puncak& Tamara, Fredo…[et al.]. The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension : a meta-analysis. The Egyptian Journal of Medical Human Genetics. 2019. Vol. 20, no. 1, pp.1-13.
https://search.emarefa.net/detail/BIM-893847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 11-13
Record ID
BIM-893847