Neurotoxic and teratogenic effects of enrofloxacin against newly hatched chicks subjected to omphalitis
Other Title(s)
تقييم التأثيرات السمية العصبية و الماسخة للإنروفلوكساسين في إفراخ الدجاج المعرضة لالتهاب السرة
Joint Authors
Abd al-Hamzah, Nibras Naib
Ibrahim, Urubah Muhammad Said
Source
Iraqi Journal of Veterinary Medicine
Issue
Vol. 43, Issue 1 (30 Jun. 2019), pp.113-123, 11 p.
Publisher
University of Baghdad College of Veterinary Medicine
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
This study was aimed to investigate any possible neurotoxic signs and teratogenic anomalies that may result from pre incubation dipping of fertile eggs in Enrofloxacin concentrations as a preventive measurement against omphalitis.
E.
Coli sensitivity against Enrofloxacin was examined in a dose dependent manner by using 2, 4, 6, 8, and 10 µg/ml.
Forty two non-infected newly hatched chicks at age of 5-7 days were divided into six groups of seven chicks each, subjected to behavioral tests namely; Open Field Test and Tonic Immobility Test.
For Open Field Test results showed that the lowest latency period was recorded significantly in chicks whose eggs dipped in 10µg/ml of Enrofloxacin (6±0.78 sec.) in comparison to control group (32.43±1.52 sec.) while the highest latency period was recorded insignificantly in chicks whose eggs dipped in 2µg/ of Enrofloxacin (29±1.61 sec.).
The highest number of lines crossed by both feet was recorded significantly in chicks whose eggs dipped in 10µg/ml of Enrofloxacin (31.43 ±2.7) in comparison to control group (12.43 ±1.02) while the lowest number of lines crossed by both feet was recorded insignificantly in chicks whose eggs dipped in 2µg/ml of Enrofloxacin (14 ±1.87).
The highest number of jumps was recorded significantly in chicks whose eggs dipped in 10µg/ml of Enrofloxacin (8.85 ±0.3) in comparison to control group (1.14 ±1.0) while the lowest number of jumps was recorded insignificantly in chicks whose eggs dipped in 2µg/ml of Enrofloxacin (2 ±0.17).
The highest number of defecation times was recorded significantly in chicks whose eggs dipped in 10µg/ml of Enrofloxacin (1.6 ±0.23) in comparison to control group (0.86 ±0.26) while the number of defecation times were insignificant in the rest of groups.
Both of call and backing times in all groups were insignificant in comparing with control group.
Results for Tonic Immobility Test showed that shortest time needed by the chick to upright itself and stand unaided was recorded significantly in chicks whose eggs dipped in 10µg/ml of Enrofloxacin (1 sec.
±0.1) in comparing with control group (2 sec.
±0.11) while the longest time needed by the chick to upright itself and stand unaided was recorded insignificantly in chicks whose eggs dipped in 2µg/ml of Enrofloxacin (1.8 sec.
±0.1).
Pre-incubation dipping of fertile eggs in Enrofloxacin concentrations showed insignificant changes in body weight, body length, leg length, wing length and beaker length.
We concluded that using low concentrations of of Enrofloxacin and Ciprofloxacin to dip eggs in has resulted in minimized neurotoxic and teratotgenic effects.
American Psychological Association (APA)
Abd al-Hamzah, Nibras Naib& Ibrahim, Urubah Muhammad Said. 2019. Neurotoxic and teratogenic effects of enrofloxacin against newly hatched chicks subjected to omphalitis. Iraqi Journal of Veterinary Medicine،Vol. 43, no. 1, pp.113-123.
https://search.emarefa.net/detail/BIM-894240
Modern Language Association (MLA)
Abd al-Hamzah, Nibras Naib& Ibrahim, Urubah Muhammad Said. Neurotoxic and teratogenic effects of enrofloxacin against newly hatched chicks subjected to omphalitis. Iraqi Journal of Veterinary Medicine Vol. 43, no. 1 (2019), pp.113-123.
https://search.emarefa.net/detail/BIM-894240
American Medical Association (AMA)
Abd al-Hamzah, Nibras Naib& Ibrahim, Urubah Muhammad Said. Neurotoxic and teratogenic effects of enrofloxacin against newly hatched chicks subjected to omphalitis. Iraqi Journal of Veterinary Medicine. 2019. Vol. 43, no. 1, pp.113-123.
https://search.emarefa.net/detail/BIM-894240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 120-122
Record ID
BIM-894240