Synthesis, characterization and preliminary anti-inflammatory evaluation of new etodolac derivatives

Abstract EN

Three new hydrazone derivatives of Etodolac were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method.

All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy, and 1HNMR analysis.

The synthesis of the target (P1-P3) compounds was accomplished following multistep reaction procedures.

The synthesized target compounds were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac).