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Flow injection analysis and spectrophotometric determination of nifedipinein pharmaceutical formulation
Other Title(s)
التقدير الطيفي للنفديبين في المستحضر الصيدلاني من خلال منظومة الحقن الجرياني
Joint Authors
al-Saidi, Intisar Muzaffar
Hasan, Sadim Subhi Abd
Source
Iraq Journal of Market Research and Consumer Protection
Issue
Vol. 11, Issue 1 (s) (30 Jun. 2019), pp.85-99, 15 p.
Publisher
University of Bagdad Market Research and Consumer Protection Center
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
15
Main Subjects
Topics
Abstract EN
A new simple and sensitive spectrophotometric method is described for quantification of Nifedipine (NIF) and their pharmaceutical formulation.
The selective method was performed by the reduction of NIF nitro group to yield primary amino group using zinc powder with hydrochloric acid.
The produced aromatic amine was submitted to oxidative coupling reaction with pyrocatechol and ammonium ceric nitrate to form orange color product measured spectrophotometrically with maximum absorption at 467nm.
The product was determined through flow injection analysis (FIA) system and all the chemical and physical parameters were optimized.
The concentration range from 5.0 to 140.0 μg.mL-1 was obeyed Beer’s law with a limit of detection and quantitation 1.48 and 4.96 μg.mL-1 respectively.
Agoodprecision,low scattering point of the calibration graph and good accuracyin addition, FIA introduced a good linear range with acceptable sensitivity.
High correlation coefficient (0.9996) was found.
The proposed method was successfully applied to assay NIF and its pharmaceutical dosage also could be utilized for pharmaceutical routine analysis of the drug.
American Psychological Association (APA)
al-Saidi, Intisar Muzaffar& Hasan, Sadim Subhi Abd. 2019. Flow injection analysis and spectrophotometric determination of nifedipinein pharmaceutical formulation. Iraq Journal of Market Research and Consumer Protection،Vol. 11, no. 1 (s), pp.85-99.
https://search.emarefa.net/detail/BIM-894825
Modern Language Association (MLA)
al-Saidi, Intisar Muzaffar& Hasan, Sadim Subhi Abd. Flow injection analysis and spectrophotometric determination of nifedipinein pharmaceutical formulation. Iraq Journal of Market Research and Consumer Protection Vol. 11, no. 1 (Special issue) (2019), pp.85-99.
https://search.emarefa.net/detail/BIM-894825
American Medical Association (AMA)
al-Saidi, Intisar Muzaffar& Hasan, Sadim Subhi Abd. Flow injection analysis and spectrophotometric determination of nifedipinein pharmaceutical formulation. Iraq Journal of Market Research and Consumer Protection. 2019. Vol. 11, no. 1 (s), pp.85-99.
https://search.emarefa.net/detail/BIM-894825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 96-99
Record ID
BIM-894825