Spectrophotometric determination of mesalazine in pharmaceutical preparations by diazotization and coupling with 2,6-dihydroxytoluene as a new coupling agent
Other Title(s)
التقدير الطيفي لمميزالازين في المستحضرات الصيدلانية بالأزوتة و الاقتران مع الكاشف 2،6 ثنائي-هيدروكسي تولوين كعامل اقتران جديد
Joint Authors
Source
Publisher
University of Mosul College of Science
Publication Date
2019-04-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
English Abstract
A simple and sensitive spectrophotometric method is proposed for the determination of mesalazine (MZ) in some of its pharmaceutical preparations.
The method is based on the diazotization of mesalazine by reaction with sodium nitrite in an acidic medium and then coupling of diazonium salt corresponding to mesalazine with 2,6-dihydroxytoluene reagent in basic medium to produce an intense orange colored water-soluble and stable azo-dye for at lest two hrs, and exhibits maximum absorption at 453 nm.
Beer’s law is obeyed in the concentration range of 2.5-100 μg of mesalazine in a final volume of 10 ml i.e.,0.25-10.0 ppm with a molar absorptivity of 4.6×104 l.
mol-1.
cm-1 and sandell sensitivity index of 0.00332 μg.
cm-2 .
A relative error is -0.48 to -4.80 and relative standard deviation of ±0.01 to ±0.17 depending on the concentration level.
The proposed method has been applied successfully to determine mesalazine in pharmaceutical preparations, tablets and suppositories.
Data Type
Conference Papers
Record ID
BIM-894926
American Psychological Association (APA)
Aziz, Ala T.& Sultan, Sad H.. 2019-04-30. Spectrophotometric determination of mesalazine in pharmaceutical preparations by diazotization and coupling with 2,6-dihydroxytoluene as a new coupling agent. Growing Chemistry Science and its Application (3 : 2019 : Banghazi, Libya). . Vol. 28, no. 2 (Special issue) (2019), pp.47-55.Mosul Iraq : University of Mosul College of Science.
https://search.emarefa.net/detail/BIM-894926
Modern Language Association (MLA)
Aziz, Ala T.& Sultan, Sad H.. Spectrophotometric determination of mesalazine in pharmaceutical preparations by diazotization and coupling with 2,6-dihydroxytoluene as a new coupling agent. . Mosul Iraq : University of Mosul College of Science. 2019-04-30.
https://search.emarefa.net/detail/BIM-894926
American Medical Association (AMA)
Aziz, Ala T.& Sultan, Sad H.. Spectrophotometric determination of mesalazine in pharmaceutical preparations by diazotization and coupling with 2,6-dihydroxytoluene as a new coupling agent. . Growing Chemistry Science and its Application (3 : 2019 : Banghazi, Libya).
https://search.emarefa.net/detail/BIM-894926
