A creative indirect spectrophotometric determination of naproxen
Other Title(s)
طريقة طيفية مستحدثة غير مباشرة لتقدير النابروكسين
Joint Authors
Mahmud, Hana Shukr
al-Siraj, Thura Z.
Source
Issue
Vol. 28, Issue 1 (28 Feb. 2019), pp.51-60, 10 p.
Publisher
University of Mosul College of Science
Publication Date
2019-02-28
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Topics
Abstract EN
A New, sensitive spectrophotometric method for determination of Naproxen (Nap) has been proposed.
The method is based on a modification of Naproxen into a hydroxy analog (mNap).
The modified compound is coupled with the diazotized p-aminobenzoic acid (PABA) in alkaline medium, the resulting orange azo dye exhibit a maximum absorption at 500 nm.
Beer's law is obeyed over the concentration range from 10 to 650 µg/20 ml, (i.e.
0.5-32.5 µg/ ml) with a good sensitivity (molar absorptivity 2.14x104 l.mol-1 .cm -1), good precision (RSD% better than ±1.93%) and high accuracy (relative error % better than 0.43%), Sandell's sensitivity index is 0.0107µg.cm-2 and the limit of detection (LOD) is 0.024 µg/ml and the limit of quantitation (LOQ) is 0.082 µg/ml.
The method has been applied successfully for determination of Naproxen in dosage forms after extraction of the active ingredient.
American Psychological Association (APA)
al-Siraj, Thura Z.& Mahmud, Hana Shukr. 2019. A creative indirect spectrophotometric determination of naproxen. Rafidain Journal of Science،Vol. 28, no. 1, pp.51-60.
https://search.emarefa.net/detail/BIM-895009
Modern Language Association (MLA)
al-Siraj, Thura Z.& Mahmud, Hana Shukr. A creative indirect spectrophotometric determination of naproxen. Rafidain Journal of Science Vol. 28, no. 1 (2019), pp.51-60.
https://search.emarefa.net/detail/BIM-895009
American Medical Association (AMA)
al-Siraj, Thura Z.& Mahmud, Hana Shukr. A creative indirect spectrophotometric determination of naproxen. Rafidain Journal of Science. 2019. Vol. 28, no. 1, pp.51-60.
https://search.emarefa.net/detail/BIM-895009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 59-60
Record ID
BIM-895009