Renoprotection by Garcinia mangostana L. pericarp extract in streptozotocin-induced diabetic mice
Other Title(s)
الحفاظ على الكلية بواسطة كارسينيا كامبوجيا في الفئران المصابة بداء السكري المستحدث بالألوكسان
Joint Authors
Ansuri, Arif Nur Muhammad
Susilo, R. J. K.
Hayaza, Suhaylah
Winarni, D.
Husayn, Saikhu Ahmad
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 33, Issue 1 (30 Jun. 2019), pp.13-19, 7 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
The purpose of this study was to evaluate the renoprotective effect of the Garcinia mangostana L.
pericarp extract (GMPE) on plasma creatinine and renal proximal tubules of streptozotocin-induced diabetic mice.
This study used 36 male Balb/c strain mice.
The samples were divided into 6 groups, namely KN (normal control), KD (diabetic control), KM (metformin control), and P (treatment group) comprising: P1 (50 mg GMPE/kg body weight), P2 (100 mg GMPE/kg body weight), as well as P3 (200 mg GMPE/kg body weight).
The GMPE and metformin suspension were administered orally for 14 days on the diabetic mice.
The diabetes was induced by intraperitoneal injection of STZ multiple at low-dose of 30 mg/kg body weight daily for five consecutive days.
On day 15, mice were terminated.
Data of plasma creatinine and renal proximal tubule damage levels or the number of swelling and necrosis cells were analyzed.
Interestingly and it showed that administration of GMPE could reduce the plasma creatinine level and ameliorate renal proximal tubules of streptozotocin-induced diabetic mice.
In conclusion, the renoprotective effect of GMPE in streptozotocin-induced diabetic mice was associated with the attenuation in oxidative stress and inflammatory, which also had antidiabetic and antioxidant activities.
American Psychological Association (APA)
Ansuri, Arif Nur Muhammad& Susilo, R. J. K.& Hayaza, Suhaylah& Winarni, D.& Husayn, Saikhu Ahmad. 2019. Renoprotection by Garcinia mangostana L. pericarp extract in streptozotocin-induced diabetic mice. Iraqi Journal of Veterinary Sciences،Vol. 33, no. 1, pp.13-19.
https://search.emarefa.net/detail/BIM-895219
Modern Language Association (MLA)
Ansuri, Arif Nur Muhammad…[et al.]. Renoprotection by Garcinia mangostana L. pericarp extract in streptozotocin-induced diabetic mice. Iraqi Journal of Veterinary Sciences Vol. 33, no. 1 (2019), pp.13-19.
https://search.emarefa.net/detail/BIM-895219
American Medical Association (AMA)
Ansuri, Arif Nur Muhammad& Susilo, R. J. K.& Hayaza, Suhaylah& Winarni, D.& Husayn, Saikhu Ahmad. Renoprotection by Garcinia mangostana L. pericarp extract in streptozotocin-induced diabetic mice. Iraqi Journal of Veterinary Sciences. 2019. Vol. 33, no. 1, pp.13-19.
https://search.emarefa.net/detail/BIM-895219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 18-19
Record ID
BIM-895219