Association of hepcidin and anemia in early chronic kidney disease
Joint Authors
Sonkar, Satyendra Kumar
Pandey, Sant Kumar
Bhosale, Vivek
Kauser, Uthman
Sonkar, Gyanendra Kumar
Singh, Neeraj
Kumar, Anil
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 2 (30 Apr. 2019), pp.315-324, 10 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-04-30
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
Hepcidin is being extensively studied for anemia and inflammation in chronic kidney disease (CKD) patients.
Hepcidin is thought to regulate iron metabolism by iron blockade through various mechanisms.
Patients with CKD have early cardiac mortality due to anemia and subclinical inflammation; hence, we studied hepcidin as a biomarker in patients with early stage of CKD in relation to anemia and inflammation.
In our cross-sectional study, a total of 80 patients were enrolled of whom, there were 25, 26, and 29 patients in CKD stages 1, 2, and 3, respectively.
Patients were divided into normal iron level (39), functional iron deficiency (FID) (18), and absolute iron deficiency (AID) (23) based on transferrin saturation and ferritin.
We found significantly high level of hepcidin (P <0.05) and high-sensitivity C-reactive protein (hsCRP) (P <0.05) in FID as compared to AID as well as normal iron level.
We also found other inflammatory markers such as albumin, transferrin, and ferritin to be significantly associated with FID.
In univariate analysis, hemoglobin (Hb) varied significantly with serum total iron-binding capacity (r = 0.40, P <0.001), log hsCRP (r = −0.32, P <0.01), and log ferritin (r = −0.23, P <0.05); however, Hb was not affected significantly with log hepcidin (r = −0.07, P >0.05).
The study indicates that among early CKD patients with FID, there was high level of hepcidin along with other inflammatory parameters, which may be associated with poor cardiovascular disease outcome due to increased inflammation.
American Psychological Association (APA)
Sonkar, Satyendra Kumar& Singh, Neeraj& Sonkar, Gyanendra Kumar& Pandey, Sant Kumar& Bhosale, Vivek& Kumar, Anil…[et al.]. 2019. Association of hepcidin and anemia in early chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 2, pp.315-324.
https://search.emarefa.net/detail/BIM-895331
Modern Language Association (MLA)
Sonkar, Gyanendra Kumar…[et al.]. Association of hepcidin and anemia in early chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 2 (Mar. / Apr. 2019), pp.315-324.
https://search.emarefa.net/detail/BIM-895331
American Medical Association (AMA)
Sonkar, Satyendra Kumar& Singh, Neeraj& Sonkar, Gyanendra Kumar& Pandey, Sant Kumar& Bhosale, Vivek& Kumar, Anil…[et al.]. Association of hepcidin and anemia in early chronic kidney disease. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 2, pp.315-324.
https://search.emarefa.net/detail/BIM-895331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 322-324
Record ID
BIM-895331