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Propolis modulates inflammatory mediators and improves histopathology in male rats with l-arginine-induced acute pancreatitis
Other Title(s)
العكبر يعدل من وسائط الالتهاب و يحسن التركيب النسيجي لذكور الجرذان المصابة بالتهاب البنكرياس الحاد المحدث بواسطة الأرجينين
Joint Authors
Jamal al-Din, Tharwat
al-Hariri, Muhammad Taha
Chathoth, Shahanas
al-Suwayyid, Abd Allah
Hashim, Tariq
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 19, Issue 2 (31 May. 2019), pp.103-107, 5 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2019-05-31
Country of Publication
Oman
No. of Pages
5
Main Subjects
Topics
Abstract EN
Objectives: This study aimed to determine the effects of propolis on immune mediators and tissue histopathology in rats with L-arginine-induced acute pancreatitis (AP).
Methods: This study was conducted at Imam Abdulrahman Bin Faisal University, Dammam, Saudia Arabia between September and November 2017.
A total of 24 male albino Wistar rats were divided into three equal groups.
Group one was the negative control, group two was the positive control (L-arginine-induced AP) and group three received treatment (L-arginineinduced AP and propolis).
The rats in group three were treated with 100 mg/kg propolis for seven days after AP induction.
Pancreatic tissue was evaluated histologically and levels of interleukin (IL)-6, IL-22 and IL-1β and tumour necrosis factor-alpha (TNF-α) were measured.
Results: Propolis reduced the quanitity of proinflammatory molecules (TNF-α, IL-1β and IL-6) in group three compared to group two, significantly increased the overall antiinflammatory effect of IL-22 (P <0.005) and reduced interstitial inflammation and neutrophil cell infiltration of the pancreatic tissues.
Conclusion: Propolis may exert a therapeutic effect in AP.
Further studies are required to demonstrate the mechanisms of propolis in AP
American Psychological Association (APA)
al-Hariri, Muhammad Taha& Jamal al-Din, Tharwat& Hashim, Tariq& Chathoth, Shahanas& al-Suwayyid, Abd Allah. 2019. Propolis modulates inflammatory mediators and improves histopathology in male rats with l-arginine-induced acute pancreatitis. Sultan Qaboos University Medical Journal،Vol. 19, no. 2, pp.103-107.
https://search.emarefa.net/detail/BIM-895455
Modern Language Association (MLA)
al-Hariri, Muhammad Taha…[et al.]. Propolis modulates inflammatory mediators and improves histopathology in male rats with l-arginine-induced acute pancreatitis. Sultan Qaboos University Medical Journal Vol. 19, no. 2 (May. 2019), pp.103-107.
https://search.emarefa.net/detail/BIM-895455
American Medical Association (AMA)
al-Hariri, Muhammad Taha& Jamal al-Din, Tharwat& Hashim, Tariq& Chathoth, Shahanas& al-Suwayyid, Abd Allah. Propolis modulates inflammatory mediators and improves histopathology in male rats with l-arginine-induced acute pancreatitis. Sultan Qaboos University Medical Journal. 2019. Vol. 19, no. 2, pp.103-107.
https://search.emarefa.net/detail/BIM-895455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 106-107
Record ID
BIM-895455