Aetiologies of hyperprolactinaemia : a retrospective analysis from a tertiary healthcare centre
Other Title(s)
مسببات فرط برولاكتين الدم : تحليل استعادي من مركز للرعاية الصحية من المستوى الثالث
Joint Authors
Aziz, Faysal
Malik, Azhar A.
Bashih, Salim A.
al-Dahmani, Khalid M.
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 19, Issue 2 (31 May. 2019), pp.129-134, 6 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2019-05-31
Country of Publication
Oman
No. of Pages
6
Main Subjects
Topics
Abstract EN
Objectives: This study aimed to evaluate the aetiologies of hyperprolactinaemia in the United Arab Emirates (UAE).
Methods: This retrospective study used laboratory databases to identify all patients who underwent evaluation for prolactin at Tawam Hospital, Al Ain, UAE, between 2009 and 2015.
Of those 2,280 patients, all patients with low or normal prolactin (n = 1,315) were excluded.
Subsequently, charts of the remaining patients (n = 965) with hyperprolactinaemia were reviewed and those with incomplete work-ups or insufficient documentation of the hyperprolactinaemia’s aetiology were excluded (n = 458).
Results: A total of 507 patients were included in the study.
The average age at prolactin evaluation was 36 ± 13.2 years and the majority (67.1%) of patients were female.
The most common reasons for requesting prolactin were menstrual disorders (29.5%), infertility (18%), evaluation of sellar masses (14.3%), ruling out seizures (13.4 %) and monitoring while on psychiatric medications (8.7%).
The most common causes of hyperprolactinaemia were prolactinoma (17%), transient hyperprolactinaemia (14.6%), drug-induced side effects (14.4%), polycystic ovarian syndrome (11.8%) and seizure disorder (7.7%).
In females, common aetiologies were prolactinomas, transient and idiopathic hyperprolactinaemia, while sellar masses, seizures, chronic kidney disease and acute illnesses were common aetiologies of hyperprolactinaemia in males.
The prolactin level varied between the different aetiologies and a level of >250 ng/mL was suggestive of macroprolactinoma.
Conclusion: A significant proportion of patients with hyperprolactinaemia have transient hyperprolactinaemia.
Before further investigations are carried out, prolactin level assessment should be repeated, especially in patients with mild hyperprolactinaemia
American Psychological Association (APA)
Malik, Azhar A.& Aziz, Faysal& Bashih, Salim A.& al-Dahmani, Khalid M.. 2019. Aetiologies of hyperprolactinaemia : a retrospective analysis from a tertiary healthcare centre. Sultan Qaboos University Medical Journal،Vol. 19, no. 2, pp.129-134.
https://search.emarefa.net/detail/BIM-895459
Modern Language Association (MLA)
Malik, Azhar A.…[et al.]. Aetiologies of hyperprolactinaemia : a retrospective analysis from a tertiary healthcare centre. Sultan Qaboos University Medical Journal Vol. 19, no. 2 (May. 2019), pp.129-134.
https://search.emarefa.net/detail/BIM-895459
American Medical Association (AMA)
Malik, Azhar A.& Aziz, Faysal& Bashih, Salim A.& al-Dahmani, Khalid M.. Aetiologies of hyperprolactinaemia : a retrospective analysis from a tertiary healthcare centre. Sultan Qaboos University Medical Journal. 2019. Vol. 19, no. 2, pp.129-134.
https://search.emarefa.net/detail/BIM-895459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 134
Record ID
BIM-895459