In silico structural analysis of the cell division protein, FtsZ : screening natural products for inhibitors
Joint Authors
al-Khayyat, Muhammad Zaghlul
al-Dabbagh, Ammar Ghanim
al-Rifai, Yusra Abd al-Razzaq
Source
al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah
Issue
Vol. 28, Issue 1 (31 Mar. 2019), pp.17-36, 20 p.
Publisher
University of Mosul College of Education for Pure Science
Publication Date
2019-03-31
Country of Publication
Iraq
No. of Pages
20
Main Subjects
Abstract EN
FtsZ is a tubulin homolog in bacteria.
It forms a Z-ring to recruit other proteins in the process of cell division through its GTPase activity.
Amino acid sequence of FtsZ was obtained from uniprot database and used for the determination of primary and secondary structures by several online tools.
Homology modeling was carried out by SWISS-MODEL and PHYRE2.
The models were evaluated and quality assessment indicated that the model produced by SWISS-MODEL had better quality than PHYRE2.
Therefore, SWISS-MODEL was used in docking twenty five natural products by AutoDock 4.2.6.
Dunnianol, pebrellin, dalbinol and hederagenin had docking energy higher than the previously used berberine and sanguinarine.
Analogs of Dunnianol were sketched by ChemBioOffice Ultra 11.0 and docked.
The analogs 2,4 and 7 had higher docking energy than the original compound.
These natural products and the analogs obtained in this study could serve as possible inhibitors of this cell division protein, a new target in the development of new antimicrobials.
American Psychological Association (APA)
al-Khayyat, Muhammad Zaghlul& al-Dabbagh, Ammar Ghanim& al-Rifai, Yusra Abd al-Razzaq. 2019. In silico structural analysis of the cell division protein, FtsZ : screening natural products for inhibitors. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah،Vol. 28, no. 1, pp.17-36.
https://search.emarefa.net/detail/BIM-895961
Modern Language Association (MLA)
al-Khayyat, Muhammad Zaghlul…[et al.]. In silico structural analysis of the cell division protein, FtsZ : screening natural products for inhibitors. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah Vol. 28, no. 1 (2019), pp.17-36.
https://search.emarefa.net/detail/BIM-895961
American Medical Association (AMA)
al-Khayyat, Muhammad Zaghlul& al-Dabbagh, Ammar Ghanim& al-Rifai, Yusra Abd al-Razzaq. In silico structural analysis of the cell division protein, FtsZ : screening natural products for inhibitors. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah. 2019. Vol. 28, no. 1, pp.17-36.
https://search.emarefa.net/detail/BIM-895961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 34-36
Record ID
BIM-895961