In silico structural analysis of the cell division protein, FtsZ : screening natural products for inhibitors

Joint Authors

al-Khayyat, Muhammad Zaghlul
al-Dabbagh, Ammar Ghanim
al-Rifai, Yusra Abd al-Razzaq

Source

al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah

Issue

Vol. 28, Issue 1 (31 Mar. 2019), pp.17-36, 20 p.

Publisher

University of Mosul College of Education for Pure Science

Publication Date

2019-03-31

Country of Publication

Iraq

No. of Pages

20

Main Subjects

Biology

Abstract EN

FtsZ is a tubulin homolog in bacteria.

It forms a Z-ring to recruit other proteins in the process of cell division through its GTPase activity.

Amino acid sequence of FtsZ was obtained from uniprot database and used for the determination of primary and secondary structures by several online tools.

Homology modeling was carried out by SWISS-MODEL and PHYRE2.

The models were evaluated and quality assessment indicated that the model produced by SWISS-MODEL had better quality than PHYRE2.

Therefore, SWISS-MODEL was used in docking twenty five natural products by AutoDock 4.2.6.

Dunnianol, pebrellin, dalbinol and hederagenin had docking energy higher than the previously used berberine and sanguinarine.

Analogs of Dunnianol were sketched by ChemBioOffice Ultra 11.0 and docked.

The analogs 2,4 and 7 had higher docking energy than the original compound.

These natural products and the analogs obtained in this study could serve as possible inhibitors of this cell division protein, a new target in the development of new antimicrobials.

American Psychological Association (APA)

al-Khayyat, Muhammad Zaghlul& al-Dabbagh, Ammar Ghanim& al-Rifai, Yusra Abd al-Razzaq. 2019. In silico structural analysis of the cell division protein, FtsZ : screening natural products for inhibitors. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah،Vol. 28, no. 1, pp.17-36.
https://search.emarefa.net/detail/BIM-895961

Modern Language Association (MLA)

al-Khayyat, Muhammad Zaghlul…[et al.]. In silico structural analysis of the cell division protein, FtsZ : screening natural products for inhibitors. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah Vol. 28, no. 1 (2019), pp.17-36.
https://search.emarefa.net/detail/BIM-895961

American Medical Association (AMA)

al-Khayyat, Muhammad Zaghlul& al-Dabbagh, Ammar Ghanim& al-Rifai, Yusra Abd al-Razzaq. In silico structural analysis of the cell division protein, FtsZ : screening natural products for inhibitors. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah. 2019. Vol. 28, no. 1, pp.17-36.
https://search.emarefa.net/detail/BIM-895961

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 34-36

Record ID

BIM-895961