Primary membranous nephropathy with concomitant IgA nephropathy
Joint Authors
Arman, Farid
Hanna, Rami M.
Khursan, Rida
Nobakht, Niloofar
Hasanayn, Huma
Hyunh, Ashley
Amin, Khalid
Rastogi, Anjay
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 2 (30 Apr. 2019), pp.531-536, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-04-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Membranous nephropathy (MN), an autoimmune glomerulonephritis which can occur in primary and secondary forms, is one of the most common inflammatory glomerulo- pathies in elderly patients.
The pathophysiology of the primary form is generally due to circulating immunoglobulin (IgG4) antibodies which often target phospholipase A2 receptors (anti- PLA2R) and Thrombospondin Type 1 Domain containing 7A (anti THSD7A).
IgA nephropathy is one of the most common autoimmune glomerular diseases in the world and presents with a spectrum of disease ranging from asymptomatic mild hematuria and proteinuria to rapidly progressive crescentic glomerulonephritis.
We present a rare case of concomitant IgA and primary MN in a single patient treated successfully with renin–angiotensin–aldosterone blockade, corticosteroids, and calcineurin inhibitors.
The peak proteinuria was near 7.5–8 g protein/g creatinine by various measures.
Serum creatinine remained normal, and anti-PLA2R was detectable and decreased with successful treatment.
Clinicians should be aware of the possibility of two glomerular disorders in patients with glomerulonephritis and atypical presentations for any single disorder.
American Psychological Association (APA)
Khursan, Rida& Hanna, Rami M.& Amin, Khalid& Arman, Farid& Nobakht, Niloofar& Rastogi, Anjay…[et al.]. 2019. Primary membranous nephropathy with concomitant IgA nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 2, pp.531-536.
https://search.emarefa.net/detail/BIM-896038
Modern Language Association (MLA)
Amin, Khalid…[et al.]. Primary membranous nephropathy with concomitant IgA nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 2 (Mar. / Apr. 2019), pp.531-536.
https://search.emarefa.net/detail/BIM-896038
American Medical Association (AMA)
Khursan, Rida& Hanna, Rami M.& Amin, Khalid& Arman, Farid& Nobakht, Niloofar& Rastogi, Anjay…[et al.]. Primary membranous nephropathy with concomitant IgA nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 2, pp.531-536.
https://search.emarefa.net/detail/BIM-896038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 535-536
Record ID
BIM-896038