Resistance to thyroid hormone
Joint Authors
al-Rumayhi, Dalal
al-Sad, Hibah Akram Ali
Alamuddin, Naji
Source
Issue
Vol. 41, Issue 3 (30 Sep. 2019), pp.182-183, 2 p.
Publisher
King Hamad University Hospital
Publication Date
2019-09-30
Country of Publication
Bahrain
No. of Pages
2
Main Subjects
Topics
Abstract EN
Resistance to thyroid hormone (RTH) is an inherited syndrome caused by a genetic mutation, which leads to a decreased response of thyroid hormone at the peripheral tissues.
It could be a challenge to diagnose because patients can be asymptomatic or present with symptoms of hyperthyroidism.
The biochemical hallmark of this syndrome is an elevated FT4, FT3 with a non-suppressed thyroid-stimulating hormone (TSH).
We report a case of thirty-five-year-old male who presented with palpitations.
A thyroid uptake scan (using intravenous Tc-99m pertechnetate) was highly suggestive of Graves’ disease.
THRβ gene showed a heterozygous c.1009A>G, p.(Thr337Ala) variant.
The result supports the clinical diagnosis of THR caused by a mutation in the THRβ gene.
He was treated with propranolol and Rivaroxaban (Xarelto) 15 mg twice daily, the ECG demonstrated controlled atrial fibrillation.
American Psychological Association (APA)
al-Sad, Hibah Akram Ali& Alamuddin, Naji& al-Rumayhi, Dalal. 2019. Resistance to thyroid hormone. Bahrain Medical Bulletin،Vol. 41, no. 3, pp.182-183.
https://search.emarefa.net/detail/BIM-896282
Modern Language Association (MLA)
al-Sad, Hibah Akram Ali…[et al.]. Resistance to thyroid hormone. Bahrain Medical Bulletin Vol. 41, no. 3 (Sep. 2019), pp.182-183.
https://search.emarefa.net/detail/BIM-896282
American Medical Association (AMA)
al-Sad, Hibah Akram Ali& Alamuddin, Naji& al-Rumayhi, Dalal. Resistance to thyroid hormone. Bahrain Medical Bulletin. 2019. Vol. 41, no. 3, pp.182-183.
https://search.emarefa.net/detail/BIM-896282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 183
Record ID
BIM-896282
