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Effect of thyroid function status in hemodialysis patients on erythropoietin resistance and interdialytic weight gain
Joint Authors
al-Sayyari, Abd Allah Ahmad
Naji, Maryam Nasir
al-Tayyib, Abd Allah A.
Hujayli, Fayiz Falih
Bin Salih, Salih
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 6 (31 Dec. 2018), pp.1274-1279, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-12-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
Thyroid function abnormalities are common in hemodialysis (HD) patients.
Here, we investigated their frequency and impact on intradialytic hemodynamics and erythropoietin resistance index (ERI).
Demographic and laboratory data including thyroid-stimulating hormone (TSH), interdialytic weight gain, and intradialytic blood pressure (BP) changes were measured, and ERI was calculated.
The prevalence and causes of abnormities in TSH and free thyroxine (FT4) and their effects on ERI and intradialytic hemodynamics were then assessed.
One hundred and thirty patients (mean age, 57.1 ± 19.2 years; 66.4% diabetic, 86.7% hypertensive) were enrolled.
Among them, 16.7% had hypothyroidism, 2.3% had hyperthyroidism, and 10.9% had subclinical hypothyroidism.
TSH level was significantly associated with higher BP (P <0.05), lower albumin (3.6 ± 4.4 and 2.6 ± 1.8, respectively; P = 0.05), lower dialysis hours (3.9 ± 5.3 and 2.6 ± 1.8, respectively), and lower ERI (3.7 ± 4.4 and 2.4 ± 1.9, respectively; P = 0.05).
FT4 was significantly associated with higher interdialytic weight gain (13.4 ± 4.3 and 11.8 ± 2.2 pmol/L, respectively; P = 0.009) and higher pre-HD diastolic BP (13.2 ± 4.0 and 12.0 ± 2.9 pmol/L, respectively; P = 0.05).
A negative correlation was seen between TSH level and urea reduction ratio (r = 0.29, P = 0.002), serum albumin (r = 0.304, P = 0.001), hemoglobin level (r = 0.26, P = 0.005), and ERI (r = 0.2, P = 0.002).
A higher TSH level was associated with hypertension, lower albumin level, fewer dialysis hours, and increased resistance to erythropoietin.
TSH level was negatively correlated with dialytic adequacy, serum albumin level, hemoglobin level, and ERI.
American Psychological Association (APA)
Bin Salih, Salih& Naji, Maryam Nasir& al-Tayyib, Abd Allah A.& Hujayli, Fayiz Falih& al-Sayyari, Abd Allah Ahmad. 2018. Effect of thyroid function status in hemodialysis patients on erythropoietin resistance and interdialytic weight gain. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 6, pp.1274-1279.
https://search.emarefa.net/detail/BIM-896375
Modern Language Association (MLA)
al-Sayyari, Abd Allah Ahmad…[et al.]. Effect of thyroid function status in hemodialysis patients on erythropoietin resistance and interdialytic weight gain. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 6 (Nov. / Dec. 2018), pp.1274-1279.
https://search.emarefa.net/detail/BIM-896375
American Medical Association (AMA)
Bin Salih, Salih& Naji, Maryam Nasir& al-Tayyib, Abd Allah A.& Hujayli, Fayiz Falih& al-Sayyari, Abd Allah Ahmad. Effect of thyroid function status in hemodialysis patients on erythropoietin resistance and interdialytic weight gain. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 6, pp.1274-1279.
https://search.emarefa.net/detail/BIM-896375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1277-1279
Record ID
BIM-896375