G6PD deficiency is not an uncommon cause of pigment nephropathy
Joint Authors
Gupta, A.
Prasad, N.
Bhaduaria, D.
Prasad, Pallavi
Kumari, Niraj
Krishnani, Narendra
Kaul, Anupma
Sharma, R. K.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 6 (31 Dec. 2018), pp.1371-1375, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-12-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Abstract EN
Acute kidney injury (AKI) with evidence of hemolysis is associated with tropical infections.
However, pigment-induced AKI can happen with relatively uncommon genetic causes of hemolytic anemia, i.e., glucose 6-phosphate deficiency (G6PD).
We share our experience of three such patients whose clinical presentation was similar to jaundice, AKI with hemolysis with suspicion of thrombotic microangiopathy.
On evaluation, all had a history of usage of anti-malarial and with G6PD estimation revealing deficient status even during the episode while other tests such as Coomb's test and bone marrow biopsy was normal in all three patients.
The kidney biopsy revealed acute tubular necrosis with red blood cell casts and pigments in all the cases.
All patients were managed conservatively and showed complete recovery.
Thus in tropical countries G6PD deficiency although is not common, should be considered among patients who have received antimalarial drugs presenting as AKI and a detailed hemolytic work-up needs to be carried out as an important cause of preventable recurrent AKI in tropical countries.
American Psychological Association (APA)
Kaul, Anupma& Prasad, Pallavi& Kumari, Niraj& Bhaduaria, D.& Sharma, R. K.& Prasad, N.…[et al.]. 2018. G6PD deficiency is not an uncommon cause of pigment nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 6, pp.1371-1375.
https://search.emarefa.net/detail/BIM-896414
Modern Language Association (MLA)
Kaul, Anupma…[et al.]. G6PD deficiency is not an uncommon cause of pigment nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 6 (Nov. / Dec. 2018), pp.1371-1375.
https://search.emarefa.net/detail/BIM-896414
American Medical Association (AMA)
Kaul, Anupma& Prasad, Pallavi& Kumari, Niraj& Bhaduaria, D.& Sharma, R. K.& Prasad, N.…[et al.]. G6PD deficiency is not an uncommon cause of pigment nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 6, pp.1371-1375.
https://search.emarefa.net/detail/BIM-896414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1374-1375
Record ID
BIM-896414