Monoclonal B-cell lymphocytosis with renal involvement

Abstract EN

We report the case of a 70-year-old man with no relevant past medical history who presented with acute kidney injury.

Kidney biopsy showed diffuse interstitial infiltration with typical chronic lymphocytic leukemia (CLL) phenotype B-cells.

Subsequent studies revealed a normal lymphocyte count in the peripheral blood, and there was no evidence of lymphadenopathy or hepatosplenomegaly.

Blood flow cytometry demonstrated a clonal B-cell population with a CLL phenotype.

Without renal involvement, this case should be classified as monoclonal B-cell lymphocytosis.

Renal function improved with steroid therapy.

However, the patient developed CLL with significant lymphocytosis approximately two years later.