Effect of olea europaea leaves extract on streptozotocin induced diabetes in male albino rats
Joint Authors
al-Salmi, Fawziyah A.
al-Attar, Atif M.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 1 (31 Jan. 2019), pp.118-128, 11 p.
Publisher
Publication Date
2019-01-31
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Topics
Abstract EN
The present study was aimed to evaluate the effect of olive (Olea europaea) leaves extract on streptozotocin (STZ)-induced diabetic male rats.
The experimental rats were divided into six groups.
Rats of the first group were served as normal controls.
Rats of the second group were diabetic control.
The third and fourth groups were diabetic rats, treated with olive leaves extract at low and high doses respectively.
The fifth and sixth groups were non diabetic rats, subjected to olive leaves extract at the same doses given to the third and fourth groups respectively.
The minimum of body weigh gain was noted in diabetic rats of the second group.
the levels of serum glucose, insulin, total protein, albumin, triglycerides, cholesterol, low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), creatine kinase (CK), lactate dehydrogenase (LDH) and malondialdehyde (MDA) were significantly increased, while the levels of high density lipoprotein cholesterol (HDL-C), superoxide dismutase, (SOD) glutathione (GSH) and catalase (CAT) were statistically decreased in diabetic rats of the second group.
The levels of liver insulin receptor substrate 1 (IRS1) and insulin receptor A (IRA) were significantly declined in diabetic rats of the second group.
The diabetic pancreatic sections from diabetic rats of the second group showed several histopathological changes.
Administration of low and high doses of olive leaves extract improved the observed physiological, molecular and histopathological alterations.
Collectively, the obtained results confirmed that the protective effects of olive leaves extract are attributed to the antioxidant activities of olive leaves extract and its active constituents
American Psychological Association (APA)
al-Attar, Atif M.& al-Salmi, Fawziyah A.. 2019. Effect of olea europaea leaves extract on streptozotocin induced diabetes in male albino rats. Saudi Journal of Biological Sciences،Vol. 26, no. 1, pp.118-128.
https://search.emarefa.net/detail/BIM-896720
Modern Language Association (MLA)
al-Attar, Atif M.& al-Salmi, Fawziyah A.. Effect of olea europaea leaves extract on streptozotocin induced diabetes in male albino rats. Saudi Journal of Biological Sciences Vol. 26, no. 1 (Jan. 2019), pp.118-128.
https://search.emarefa.net/detail/BIM-896720
American Medical Association (AMA)
al-Attar, Atif M.& al-Salmi, Fawziyah A.. Effect of olea europaea leaves extract on streptozotocin induced diabetes in male albino rats. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 1, pp.118-128.
https://search.emarefa.net/detail/BIM-896720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 126-128
Record ID
BIM-896720