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Epidemiological characterization of serotype group B streptococci neonatal infections associated with interleukin-6 level as a sensitive parameter for the early diagnosis
Joint Authors
al-Hazzani, Amal A.
Bawazir, Riham A. B.
Shihatah, Afaf I.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 7 (30 Nov. 2018), pp.1356-1364, 9 p.
Publisher
Publication Date
2018-11-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
- Medical diagnosis
- Diagnosis
- Molecular aspects
- Streptococcus agalactiae
- Interleukin-6
- Molecular epidemiology
Abstract EN
Group B streptococcal infection (Streptococcus agalactiae) is one of the leading causes of life-threatening disease in the early neonatal period, resulting in sepsis, pneumonia, and meningitis.
During invasive infections, an excessive release of pro-inflammatory cytokine, such as interleukin-6 (IL-6), thus IL-6 gene is significant, as a diagnostic marker of systemic infection of the newborns.
The present study aimed to describe the epidemiology diagnostic of GBS disease in neonatal by phenotypic and genotypic methods.
Nine hundred and ninety-six samples were taken at Maternity and Children Hospital, Jeddah, Saudi Arabia for a period of one year (2011–2012).
Results indicated that out of 217 infected samples, twenty (9.23.0%) were positive for group B Streptococci bacteria.
This study also shows that female infants are more susceptible than males.
The level of IL-6 was higher in mothers above 30 years.
Twenty positive Streptococci group B isolates showed bands with the cylE gene primers in the border between 228 bp, 267 bp and 50 bp.
Molecular detection by Real time polymerase chain reaction was also done to detect the target (Sip gene) encoding the Sip surface immunogenic protein.
Specific primers and TaqMan probe were chosen for this purpose.
A Real-time PCR method targeting the sip gene of GBS in neonates after delivery has been evaluated.
American Psychological Association (APA)
al-Hazzani, Amal A.& Bawazir, Riham A. B.& Shihatah, Afaf I.. 2018. Epidemiological characterization of serotype group B streptococci neonatal infections associated with interleukin-6 level as a sensitive parameter for the early diagnosis. Saudi Journal of Biological Sciences،Vol. 25, no. 7, pp.1356-1364.
https://search.emarefa.net/detail/BIM-896725
Modern Language Association (MLA)
al-Hazzani, Amal A.…[et al.]. Epidemiological characterization of serotype group B streptococci neonatal infections associated with interleukin-6 level as a sensitive parameter for the early diagnosis. Saudi Journal of Biological Sciences Vol. 25, no. 7 (Nov. 2018), pp.1356-1364.
https://search.emarefa.net/detail/BIM-896725
American Medical Association (AMA)
al-Hazzani, Amal A.& Bawazir, Riham A. B.& Shihatah, Afaf I.. Epidemiological characterization of serotype group B streptococci neonatal infections associated with interleukin-6 level as a sensitive parameter for the early diagnosis. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 7, pp.1356-1364.
https://search.emarefa.net/detail/BIM-896725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1363-1364
Record ID
BIM-896725