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Down-regulation of microRNA-200b is a potential prognostic marker of lung cancer in Southern-Central Chinese population
Joint Authors
Li, Wen
Jia, Ming Xi
Lin, Qin Lu
Liu, Cun
Wang, Sha Sha
Tang, Jian Xin
Zeng, Xiao Xi
Cai, Fang
Zhou, Li Yi
Wang, Jian Hui
Liu, Xue Ying
Ma, Liang
Su, Wei
Deng, Jing
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 1 (31 Jan. 2019), pp.173-177, 5 p.
Publisher
Publication Date
2019-01-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
MicroRNAs (miRNAs) may regulate diverse biological processes and play an important role in cancer.
And MiRNAs have been proposed as a useful tool for lung cancer diagnosis and therapeutics in cancer.
The purpose of the present study was to investigate the association among the expression level of mature miR-200b-5p in peripheral blood and the risk of lung cancer and clinic pathological characteristics.
This case-control study included 24 patients with lung cancer and 12 healthy controls.
MiR-200b expression was deleted using real-time PCR.
and the miR-200b expression of normal controls was significantly higher than that in lung cancer patients (1732.13 pg/mL vs 881.67 pg/mL, P < 0.05), no difference with age, sex, tissue type and clinical stage of lung cancer patients (P > 0.05).
Furthermore, miR-200b expression level fluctuated with tumor progression in lung cancer, and there was highly significant for clinical stage II compared with the clinical stage III (P < 0.05).
In addition, the down-regulation of miR-200b showed a highly discriminative receiver operating characteristic (ROC) curve profile, clearly distinguishing cancer patients from cancer-free subjects with an area under the ROC curve (AUROC) of 0.87.
The detection of miR-200b expression yielded 83.30% sensitivity and 100.00% specificity in the diagnosis of lung cancer.
Therefore, these findings suggested that miR-200b may be used as a marker for the detection and diagnosis of lung cancer in peripheral blood.
American Psychological Association (APA)
Li, Wen& Jia, Ming Xi& Deng, Jing& Wang, Jian Hui& Lin, Qin Lu& Tang, Jian Xin…[et al.]. 2019. Down-regulation of microRNA-200b is a potential prognostic marker of lung cancer in Southern-Central Chinese population. Saudi Journal of Biological Sciences،Vol. 26, no. 1, pp.173-177.
https://search.emarefa.net/detail/BIM-896756
Modern Language Association (MLA)
Li, Wen…[et al.]. Down-regulation of microRNA-200b is a potential prognostic marker of lung cancer in Southern-Central Chinese population. Saudi Journal of Biological Sciences Vol. 26, no. 1 (Jan. 2019), pp.173-177.
https://search.emarefa.net/detail/BIM-896756
American Medical Association (AMA)
Li, Wen& Jia, Ming Xi& Deng, Jing& Wang, Jian Hui& Lin, Qin Lu& Tang, Jian Xin…[et al.]. Down-regulation of microRNA-200b is a potential prognostic marker of lung cancer in Southern-Central Chinese population. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 1, pp.173-177.
https://search.emarefa.net/detail/BIM-896756
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 176-177
Record ID
BIM-896756