Spectrum of renal allograft biopsy : a five-year experience at a tertiary care center of eastern India
Joint Authors
Patil, Malagouda R.
Divyaveer, Smita Subhash
Mahajan, Chetan
Choudhury, Arpita Roy
Dasgupta, Sanjay
Riyait, Harmeet
Pandey, Rajendra
Abraham, Anila
Sarkar, Dipankar
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 4 (31 Aug. 2018), pp.930-938, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-08-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Renal allograft dysfunction (RAD) can have myriad causes and presentations.
Allograft biopsy remains the gold standard for optimum management.
This is a retrospective study carried out at a tertiary care institute from August 2011 to March 2016.
Details of the renal allograft biopsy requisitions were recorded and analyzed.
Two hundred and two patients had undergone kidney transplantation (KT) during the study period.
One hundred and twenty-six had undergone renal biopsy for RAD.
The acute asymptomatic rise of serum creatinine was the most common clinical presentation (47.61%) followed by chronic RAD (CRAD) (19.84%), proteinuria (15.87%), immediate graft dysfunction (10.31%), and persistent active urinary sediments (6.34%) in that order.
The incidence of delayed graft function was 1.98%.
The overall incidence of biopsyproven rejection was 8.41% within oneyear and 8.91% beyond oneyear of transplant.
Acute cellular rejection (ACR) [with or without antibody-mediated rejection (AMR)] was found in 65%; AMR was found in 40% and 15% had both ACR and AMR.
Borderline acute cell-mediated rejection was found in 22.5% of biopsies.
CRAD was due to chronic rejection and chronic calcineurin inhibitor toxicity in only about one-fourth of the cases.
Incidence of glomerulonephritis was 10.89% and most of these occurred two years after KT.
Renal allograft biopsy was associated with minor complications in 3.17% of cases.
Clinical presentations do not reliably distinguish the various causes of RAD.
Allograft biopsy is a mainstay in the diagnosis of RAD and is safe.
Results of live donor first transplantation using complement-dependent cytotoxicity crossmatch are comparable to those programs using newer methods like solid-phase assays.
However, the direct comparison of these results with other studies may not be completely applicable.
American Psychological Association (APA)
Patil, Malagouda R.& Divyaveer, Smita Subhash& Mahajan, Chetan& Choudhury, Arpita Roy& Dasgupta, Sanjay& Sarkar, Dipankar…[et al.]. 2018. Spectrum of renal allograft biopsy : a five-year experience at a tertiary care center of eastern India. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 4, pp.930-938.
https://search.emarefa.net/detail/BIM-896763
Modern Language Association (MLA)
Patil, Malagouda R.…[et al.]. Spectrum of renal allograft biopsy : a five-year experience at a tertiary care center of eastern India. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 4 (Jul. / Aug. 2018), pp.930-938.
https://search.emarefa.net/detail/BIM-896763
American Medical Association (AMA)
Patil, Malagouda R.& Divyaveer, Smita Subhash& Mahajan, Chetan& Choudhury, Arpita Roy& Dasgupta, Sanjay& Sarkar, Dipankar…[et al.]. Spectrum of renal allograft biopsy : a five-year experience at a tertiary care center of eastern India. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 4, pp.930-938.
https://search.emarefa.net/detail/BIM-896763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 937-938
Record ID
BIM-896763